| ubiquitin-protein ligase activity, IEA | 281 genes |
| ubiquitin ligase complex, IEA | 254 genes |
| UCH, Ubiquitin carboxyl-terminal hydrolase | 71 genes |
| ubiquitin cycle, IEA | 67 genes |
| ubiquitin-dependent protein catabolism, IEA | 60 genes |
| ubiquitin, Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue), Nedd8, Elongin B, Rub1 | 55 genes |
| UQ_con, Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC h | 43 genes |
| ubiquitin thiolesterase activity, IEA | 40 genes |
| ubiquitin conjugating enzyme activity, IEA | 35 genes |
| UPF0242, Uncharacterised protein family (UPF0242) | 29 genes |
| ubiquitin-dependent protein catabolism, TAS | 25 genes |
| UDPGT, UDP-glucoronosyl and UDP-glucosyl transferase | 24 genes |
| ubiquitin conjugating enzyme activity, TAS | 21 genes |
| UBA, UBA/TS-N domain. This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins havi | 19 genes |
| ubiquitin-protein ligase activity, TAS | 17 genes |
| ubiquitin-protein ligase activity, NAS | 15 genes |
| Ubie_methyltran, ubiE/COQ5 methyltransferase family | 13 genes |
| Utp14, Utp14 protein. This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA proces | 13 genes |
| ubiquitin ligase complex, NAS | 13 genes |
| UBX, UBX domain. Domain present in ubiquitin-regulatory proteins. Present in FAF1 and Shp1p | 12 genes |
| UPF0073, Uncharacterised protein family (Hly-III / UPF0073). Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It is not clear if all the members of this family | 12 genes |
| uDENN, uDENN domain. This region is always found associated with pfam02141. It is predicted to form an all beta domain | 12 genes |
| UTP biosynthesis, IEA | 10 genes |
| UPAR_LY6, u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087 | 9 genes |
| UPF0005, Uncharacterised protein family UPF0005 | 8 genes |
| ubiquitin-dependent protein catabolism, NAS | 8 genes |
| UvrD-helicase, UvrD/REP helicase. The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. Some members h | 7 genes |
| Uteroglobin, Uteroglobin family. Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated | 7 genes |
| ubiquitin ligase complex, TAS | 7 genes |
| U-box, U-box domain. This domain is related to the Ring finger pfam00097 but lacks the zinc binding residues | 6 genes |
| uridine kinase activity, IEA | 6 genes |
| UPF0020, Putative RNA methylase family UPF0020. This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains | 5 genes |
| UBACT, Repeat in ubiquitin-activating (UBA) protein | 5 genes |
| UPF0227, Uncharacterised protein family (UPF0227). Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes that are distantly related to the pfam00561 | 5 genes |
| ubiquitin thiolesterase activity, TAS | 5 genes |
| ubiquitin-protein ligase activity, IDA | 4 genes |
| uracil DNA N-glycosylase activity, TAS | 4 genes |
| UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity, TAS | 4 genes |
| UbiA, UbiA prenyltransferase family | 3 genes |
| UPP_synthetase, Putative undecaprenyl diphosphate synthase. Previously known as uncharacterized protein family UPF0015, a single member of this family has been identified as an undecaprenyl diphosphate synthase | 3 genes |
| UDPGP, UTP--glucose-1-phosphate uridylyltransferase. This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--gluco | 3 genes |
| UDG, Uracil DNA glycosylase superfamily | 3 genes |
| UPF0136, Uncharacterized protein family (UPF0136). This family of short membrane proteins are as yet uncharacterized | 3 genes |
| UPF0041, Uncharacterised protein family (UPF0041) | 3 genes |
| UMPH-1, Pyrimidine 5'-nucleotidase (UMPH-1). This family consists of several eukaryotic pyrimidine 5'-nucleotidase proteins. P5'N-1, also known as uridine monophosphate hydrolase-1 (UMPH-1), is a member of a large functional group of enzymes, | 3 genes |
| UPF0240, Uncharacterised protein family (UPF0240) | 3 genes |
| ubiquitin activating enzyme activity, IEA | 3 genes |
| ubiquinone biosynthesis, IEA | 3 genes |
| ubiquinol-cytochrome-c reductase activity, IEA | 3 genes |
| ubiquinol-cytochrome-c reductase activity, NAS | 3 genes |
| UV protection, TAS | 3 genes |
| ubiquinol-cytochrome-c reductase complex (sensu Eukarya), IEA | 3 genes |
| uncoupling protein activity, TAS | 3 genes |
| U6 snRNA binding, NAS | 3 genes |
| UPF0004, Uncharacterized protein family UPF0004. This family is the N terminal half of proteins with a C-terminal half, which has been shown to be related to MiaB proteins. This domain is a nearly always found in conjunction with pfam04055 and | 2 genes |
| UPF0103, Protein of unknown function DUF52. This family contains members from all branches of life. The function of this protein is unknown | 2 genes |
| UCR_hinge, Ubiquinol-cytochrome C reductase hinge protein. The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex. This Pfam family represents the 'hinge' protein of the complex which is thou | 2 genes |
| UCR_TM, Ubiquinol cytochrome reductase transmembrane region. Each subunit of the cytochrome bc1 complex provides a single helix (this family) to make up the transmembrane region of the complex | 2 genes |
| UT, Urea transporter. Members of this family transport urea across membranes. The family includes a bacterial homologue | 2 genes |
| UPF0172, Uncharacterised protein family (UPF0172) | 2 genes |
| UPF0197, Uncharacterized protein family (UPF0197). This family of proteins is functionally uncharacterized | 2 genes |
| UPF0224, Uncharacterized protein family (UPF0224). This family of proteins is functionally uncharacterized | 2 genes |
| UPF0203, Uncharacterised protein family (UPF0203). This family of proteins is functionally uncharacterised | 2 genes |
| UPF0220, Uncharacterized protein family (UPF0220). This family of proteins is functionally uncharacterized | 2 genes |
| UDP-g_GGTase, UDP-glucose:Glycoprotein Glucosyltransferase. The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase | 2 genes |
| UPF0258, Uncharacterised protein family (UPF0258) | 2 genes |
| urea cycle, IEA | 2 genes |
| urea cycle, NR | 2 genes |
| urea cycle, TAS | 2 genes |
| ubiquitin activating enzyme activity, TAS | 2 genes |
| ubiquitin conjugating enzyme activity, NR | 2 genes |
| UDP-galactose transporter activity, TAS | 2 genes |
| UDP-glucose metabolism, TAS | 2 genes |
| ubiquitin cycle, IDA | 2 genes |
| ubiquitin cycle, NAS | 2 genes |
| ubiquinone biosynthesis, TAS | 2 genes |
| ubiquinol-cytochrome-c reductase activity, TAS | 2 genes |
| UDP-glycosyltransferase activity, TAS | 2 genes |
| UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity, NAS | 2 genes |
| urea transporter activity, TAS | 2 genes |
| urea transport, TAS | 2 genes |
| unconventional myosin, TAS | 2 genes |
| Usher, Fimbrial Usher protein. This protein is involved in biogenesis of gram negative bacterial pili | 1 genes |
| UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase family, central domain. The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to a | 1 genes |
| UPF0027, Uncharacterized protein family UPF0027 | 1 genes |
| UPF0016, Uncharacterized protein family UPF0016. This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three p | 1 genes |
| UPF0023, Uncharacterized protein family UPF0023. This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and human | 1 genes |
| Urocanase, Urocanase | 1 genes |
| UPF0029, Uncharacterized protein family UPF0029 | 1 genes |
| URO-D, Uroporphyrinogen decarboxylase (URO-D) | 1 genes |
| UPF0118, Domain of unknown function DUF20. This transmembrane region is found in putative permeases and predicted transmembrane proteins it has no known function. It is not clear what source suggested that these proteins may be permeases and t | 1 genes |
| UPF0086, Domain of unknown function UPF0086. This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease | 1 genes |
| UPF0066, Uncharacterized protein family UPF0066 | 1 genes |
| UPF0099, Domain of unknown function UPF0099. This domain has no known function | 1 genes |
| UPF0054, Uncharacterized protein family UPF0054 | 1 genes |
| UCR_14kD, Ubiquinol-cytochrome C reductase complex 14kD subunit. The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex. This Pfam family represents the 14kD (or VI) subunit of the complex wh | 1 genes |
| UPF0061, Uncharacterized ACR, YdiU/UPF0061 family | 1 genes |
| UcrQ, UcrQ family. The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex. This family represents the 9.5 kDa subunit of the complex | 1 genes |
| U79_P34, HSV U79 / HCMV P34. This family represents herpes virus protein U79 and cytomegalovirus early phosphoprotein P34 (UL112) | 1 genes |
| UFD1, Ubiquitin fusion degradation protein UFD1. Post-translational ubiquitin-protein conjugates are recognised for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified. | 1 genes |
| UPF0108, Uncharacterized protein family (UPF0108) | 1 genes |
| UPF0113, Uncharacterised protein family (UPF0113) | 1 genes |
| UPF0121, Uncharacterized protein family (UPF0121). Uncharacterized integral membrane protein family | 1 genes |
| UPF0171, Uncharacterized protein family (UPF0171) | 1 genes |
| UPF0139, Uncharacterised protein family (UPF0139) | 1 genes |
| UPF0184, Uncharacterized protein family (UPF0184) | 1 genes |
| UPF0185, Uncharacterized protein family (UPF0185). This family contains a number of small uncharacterized proteins including BM-002 | 1 genes |
| UPF0131, Uncharacterised protein family (UPF0131). This family of proteins are uncharacterised, however BtrG is part of a butirosin-biosynthetic gene cluster from Bacillus circulans | 1 genes |
| UPF0183, Uncharacterised protein family (UPF0183). This family of proteins includes Lin-10 from C. elegans | 1 genes |
| UPF0160, Uncharacterized protein family (UPF0160). This family of proteins contains a large number of metal binding residues. The patterns are suggestive of a phosphoesterase function. The conserved DHH motif may mean this family is related to | 1 genes |
| UPF0120, Uncharacterised protein family (UPF0120). At least one member, Nco2p from yeast, is required for a late step in 60S subunit export from the nucleus. It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required f | 1 genes |
| UDPG_MGDP_dh_C, UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain. The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcoho | 1 genes |
| UDPG_MGDP_dh_N, UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain. The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcoho | 1 genes |
| Ubiq_cyt_C_chap, Ubiquinol-cytochrome C chaperone | 1 genes |
| Utp11, Utp11 protein. This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA proces | 1 genes |
| Utp12, Dip2/Utp12 Family. This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2 | 1 genes |
| Upf2, Up-frameshift suppressor 2. Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae | 1 genes |
| Utp21, Utp21 specific WD40 associated putative domain. Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA | 1 genes |
| Uso1_p115_head, Uso1 / p115 like vesicle tethering protein, head region. Also known as General vesicular transport factor, Transcytosis associated protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal | 1 genes |
| Uso1_p115_C, Uso1 / p115 like vesicle tethering protein, C terminal region. Also known as General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-termin | 1 genes |
| UNC-50, UNC-50 family. This family contains several eukaryotic transmembrane proteins which are related to the C. elegans protein UNC-50 | 1 genes |
| UPF0193, Uncharacterized protein family (UPF0193). This family of proteins is functionally uncharacterized | 1 genes |
| UMP1, Proteasome maturation factor UMP1. UMP1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. UMP1 is required for the correct assembly and enzymatic activation of the proteasome | 1 genes |
| UCR_UQCRX_QCR9, Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like. The UQCRX/QCR9 protein is the 9/10 subunit of complex III, encoding a protein of about 7-kDa. Deletion of QCR9 results in the inability of cells to grow on grow on-fermentable | 1 genes |
| UPF0239, Uncharacterised protein family (UPF0239) | 1 genes |
| Uroplakin_II, Uroplakin II. This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of | 1 genes |
| urea cycle, NAS | 1 genes |
| urotensin II receptor activity, IEA | 1 genes |
| UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity, IEA | 1 genes |
| UDP-N-acetylglucosamine diphosphorylase activity, TAS | 1 genes |
| UDP-glucose 4-epimerase activity, NR | 1 genes |
| UDP-glucose 6-dehydrogenase activity, TAS | 1 genes |
| UDP-glucose:glycoprotein glucosyltransferase activity, TAS | 1 genes |
| UTP-hexose-1-phosphate uridylyltransferase activity, IEA | 1 genes |
| UTP-hexose-1-phosphate uridylyltransferase activity, TAS | 1 genes |
| UTP-glucose-1-phosphate uridylyltransferase activity, TAS | 1 genes |
| ubiquitin activating enzyme activity, NR | 1 genes |
| ubiquitin conjugating enzyme activity, NAS | 1 genes |
| ubiquitin-protein ligase activity, NR | 1 genes |
| ubiquitin-specific protease activity, TAS | 1 genes |
| uridine kinase activity, TAS | 1 genes |
| uridine phosphorylase activity, IEA | 1 genes |
| uridine phosphorylase activity, TAS | 1 genes |
| uroporphyrinogen-III synthase activity, IEA | 1 genes |
| uroporphyrinogen decarboxylase activity, IEA | 1 genes |
| uroporphyrinogen decarboxylase activity, TAS | 1 genes |
| UDP-N-acetylglucosamine transporter activity, TAS | 1 genes |
| UDP-N-acetylgalactosamine transporter activity, NAS | 1 genes |
| UDP-N-acetylglucosamine metabolism, IEA | 1 genes |
| UDP-N-acetylglucosamine metabolism, TAS | 1 genes |
| UDP-N-acetylglucosamine biosynthesis, TAS | 1 genes |
| UDP-glucuronate biosynthesis, TAS | 1 genes |
| uracil catabolism, NAS | 1 genes |
| UMP biosynthesis, TAS | 1 genes |
| UDP catabolism, IDA | 1 genes |
| ubiquitin-dependent protein catabolism, NR | 1 genes |
| ubiquitin cycle, TAS | 1 genes |
| uroporphyrinogen III biosynthesis, TAS | 1 genes |
| unfolded protein response, positive regulation of target gene transcription, TAS | 1 genes |
| ultradian rhythm, IDA | 1 genes |
| UDP-glucose-hexose-1-phosphate uridylyltransferase activity, IEA | 1 genes |
| UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase activity, TAS | 1 genes |
| ubiquitin-specific protease 5 activity, TAS | 1 genes |
| ubiquitin-like activating enzyme activity, TAS | 1 genes |
| UDP-N-acetylglucosamine 2-epimerase activity, TAS | 1 genes |
| UDP-sugar diphosphatase activity, IEA | 1 genes |
| unidimensional cell growth, IMP | 1 genes |
| ubiquinol-cytochrome-c reductase complex (sensu Eukarya), NAS | 1 genes |
| ubiquinol-cytochrome-c reductase complex (sensu Eukarya), TAS | 1 genes |
| uridine nucleotide receptor activity, TAS | 1 genes |
| urea transporter activity, IEA | 1 genes |
| uncoupling protein activity, NR | 1 genes |
| UDP-galactose transport, TAS | 1 genes |
| UDP-N-acetylglucosamine transport, TAS | 1 genes |
| UDP-N-acetylgalactosamine transport, NAS | 1 genes |
| urea transport, IEA | 1 genes |
| urocanate hydratase activity, IEA | 1 genes |
| unconventional myosin, NAS | 1 genes |
| ubiquitin-like-protein ligase activity, IDA | 1 genes |
| ubiquitin-like-protein ligase activity, TAS | 1 genes |
| U-plasminogen activator receptor activity, IEA | 1 genes |
| ubiquitin binding, IDA | 1 genes |
| ubiquitin binding, NAS | 1 genes |
| UDP-activated nucleotide receptor activity, NAS | 1 genes |
| uridine diphosphatase activity, IDA | 1 genes |
| unmethylated CpG binding, IDA | 1 genes |
| urothelial cell proliferation, IDA | 1 genes |