| biological_process unknown, ND | 335 genes |
| BTB, BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch | 119 genes |
| Borrelia_P83, Borrelia P83/100 protein. This family consists of several Borrelia P83/P100 antigen proteins | 52 genes |
| binding, IEA | 52 genes |
| biosynthesis, IEA | 47 genes |
| bZIP, bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region | 44 genes |
| Bromodomain, Bromodomain. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine | 41 genes |
| BSP_II, Bone sialoprotein II (BSP-II). Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts. The expression of bone sialoprotein (BSP) is normally restricte | 38 genes |
| Band_41, FERM domain (Band 4.1 family). This domain has been renamed the FERM domain, which stands for F for 4.1, E for Ezrin, R for radixin and M for moesin | 37 genes |
| blood coagulation, TAS | 33 genes |
| blood coagulation, IEA | 20 genes |
| brain development, TAS | 17 genes |
| BRCT, BRCA1 C Terminus (BRCT) domain. The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. It has been suggested that the Retinoblastoma protein contains a divergent BRCT doma | 15 genes |
| binding, TAS | 15 genes |
| BAH, BAH domain. This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction | 14 genes |
| BTK, BTK motif. Zinc-binding motif containing conserved cysteines and a histidine. Always found C-terminal to PH domains. The crystal structure shows this motif packs against the PH domain. The PH+Btk module pair has been called the Tec homolo | 12 genes |
| behavior, TAS | 12 genes |
| Band_7, SPFH domain / Band 7 family. This family also includes proteins with high blast scores to known Band 7 protein: HflC from E. coli, HflK from E. coli, Prohibitin family members | 11 genes |
| BLVR, Bovine leukaemia virus receptor (BLVR). This family consists of several bovine specific leukaemia virus receptors which are thought to function as transmembrane proteins, although their exact function is unknown | 11 genes |
| Bcl-2, Apoptosis regulator proteins, Bcl-2 family | 10 genes |
| Biotin_lipoyl, Biotin-requiring enzyme. This family covers two subgroups, the conserved lysine residue binds biotin in one group and lipoic acid in the other | 9 genes |
| BIR, Inhibitor of Apoptosis domain. BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat' Also known as IAP repeat | 9 genes |
| blood coagulation, NR | 9 genes |
| BAR, BAR domain. The BAR domain is found in amphiphysin and clathrin binding protein. However the function of this domain is unknown | 8 genes |
| bZIP_Maf, bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property. Thus, this family is probably related to pfam00170 | 8 genes |
| BRICHOS, BRICHOS domain. The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer | 8 genes |
| basement membrane, TAS | 8 genes |
| Beach, Beige/BEACH domain | 7 genes |
| BAF1_ABF1, BAF1 / ABF1 chromatin reorganising factor. ABF1 is a sequence-specific DNA binding protein involved in transcription activation, gene silencing and initiation of DNA replication. ABF1 is known to remodel chromatin, and it is propose | 7 genes |
| Branch, Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-an | 6 genes |
| Brix, Brix domain | 6 genes |
| basement membrane, IEA | 6 genes |
| base-excision repair, TAS | 6 genes |
| benzodiazepine receptor activity, TAS | 6 genes |
| Bestrophin, Bestrophin. Bestrophin is a 68-kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a de | 5 genes |
| B56, Protein phosphatase 2A regulatory B subunit (B56 family). Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed het | 5 genes |
| Bindin, Bindin | 5 genes |
| BAG, BAG domain. Domain present in Hsp70 regulators | 5 genes |
| Biotin_carb_C, Biotin carboxylase C-terminal domain. Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most | 5 genes |
| BRO1, BRO1-like domain. This functionally uncharacterized domain is found in a number of signal transduction proteins, including Rhophilin and BRO1 | 5 genes |
| BEX, Brain expressed X-linked like family | 5 genes |
| BASP1, Brain acid soluble protein 1 (BASP1 protein). This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of | 5 genes |
| basement membrane, NR | 5 genes |
| beta-tubulin folding, TAS | 5 genes |
| brain development, NAS | 5 genes |
| B-cell differentiation, NAS | 5 genes |
| B-cell differentiation, TAS | 5 genes |
| bone mineralization, NAS | 5 genes |
| B-cell activation, IEA | 5 genes |
| Biopterin_H, Biopterin-dependent aromatic amino acid hydroxylase. This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein | 4 genes |
| Basic, Myogenic Basic domain. This basic domain is found in the MyoD family of muscle specific proteins that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHL | 4 genes |
| Borrelia_orfA, Borrelia ORF-A. This protein is encoded by an open reading frame in plasmid borne DNA repeats of Borrelia species. This protein is known as ORF-A. The function of this putative protein is unknown | 4 genes |
| BSD, BSD domain. This domain contains a distinctive -FW- motif. It is found in a family of eukaryotic transcription factors as well as a set of proteins of unknown function | 4 genes |
| Bile_Hydr_Trans, Acyl-CoA thioester hydrolase / Bile acid-CoA amino acid N-acetyltransferase. This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT). This region is not | 4 genes |
| biotin carboxylase activity, IEA | 4 genes |
| basal lamina, TAS | 4 genes |
| base-excision repair, IEA | 4 genes |
| bile acid metabolism, TAS | 4 genes |
| biotin carboxylase complex, IEA | 4 genes |
| BolA, BolA-like protein. This family consist of the morphoprotein BolA from E. coli and its various homologues. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and | 3 genes |
| BH4, Bcl-2 homology region 4 | 3 genes |
| BPL_LipA_LipB, Biotin/lipoate A/B protein ligase family. This family includes biotin protein ligase, lipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbon | 3 genes |
| BK_channel_a, Calcium-activated BK potassium channel alpha subunit | 3 genes |
| BCL_N, BCL7, N-terminal conserver region. Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In a | 3 genes |
| Baculo_IE-1, Baculovirus immediate-early protein (IE-0). The Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV) ie-1 gene product (IE-1) is thought to play a central role in stimulating early viral transcription. IE-1 | 3 genes |
| Bap31, B-cell receptor-associated protein 31-like. Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8. Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31 | 3 genes |
| B9, B9 protein. This family represents a conserved region approximately 100 residues long within the eukaryotic protein B9. B9 has been isolated from endothelial precursor cells | 3 genes |
| beta-amyloid binding, NAS | 3 genes |
| beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, IEA | 3 genes |
| beta-galactoside alpha-2,3-sialyltransferase activity, TAS | 3 genes |
| brush border, TAS | 3 genes |
| blood coagulation, NAS | 3 genes |
| behavior, NAS | 3 genes |
| bacterial binding, TAS | 3 genes |
| biotin binding, IEA | 3 genes |
| bile acid transporter activity, TAS | 3 genes |
| basic amino acid transporter activity, TAS | 3 genes |
| bicarbonate transport, NAS | 3 genes |
| bile acid catabolism, IEA | 3 genes |
| B-cell proliferation, NAS | 3 genes |
| BcrAD_BadFG, BadF/BadG/BcrA/BcrD ATPase family. This family includes the BadF and BadG proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzym | 2 genes |
| B12-binding, B12 binding domain. This domain binds to B12 (adenosylcobamide), it is found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase | 2 genes |
| Big_2, Bacterial Ig-like domain (group 2). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial and phage surface proteins such as intimins | 2 genes |
| BAF, Barrier to autointegration factor. The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif. The protein is involved in the prevention of retroviral DNA inte | 2 genes |
| BTV_NS2, Bluetongue virus non-structural protein NS2. This family includes NS2 proteins from other members of the Orbivirus genus. NS2 is a non-specific single-stranded RNA-binding protein that forms large homomultimers and accumulates in vira | 2 genes |
| BDV_P40, Borna disease virus P40 protein. This family consists of several Borna disease virus P40 proteins. Borna disease (BD) is a persistent viral infection of the central nervous system caused by the single-negative-strand, nonsegmented RNA | 2 genes |
| BNIP3, BNIP3. This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypica | 2 genes |
| Bin3, Bicoid-interacting protein 3 (Bin3). This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases th | 2 genes |
| BAT2_N, BAT2 N-terminus. This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, | 2 genes |
| beta-amyloid binding, ISS | 2 genes |
| beta-galactoside alpha-2,6-sialyltransferase activity, ISS | 2 genes |
| biliverdin reductase activity, TAS | 2 genes |
| bisphosphoglycerate phosphatase activity, IEA | 2 genes |
| branched-chain-amino-acid transaminase activity, TAS | 2 genes |
| beta-glucuronidase activity, TAS | 2 genes |
| bombesin receptor activity, TAS | 2 genes |
| bradykinin receptor activity, TAS | 2 genes |
| binding, NR | 2 genes |
| brush border, NR | 2 genes |
| bile acid biosynthesis, TAS | 2 genes |
| binding of sperm to zona pellucida, TAS | 2 genes |
| brain development, ISS | 2 genes |
| beta-catenin binding, TAS | 2 genes |
| bile acid:sodium symporter activity, TAS | 2 genes |
| branched chain family amino acid biosynthesis, TAS | 2 genes |
| branched chain family amino acid catabolism, IEA | 2 genes |
| beta-galactosidase complex, IEA | 2 genes |
| biotin binding, TAS | 2 genes |
| basal plasma membrane, NAS | 2 genes |
| bile acid transport, TAS | 2 genes |
| basolateral plasma membrane, NAS | 2 genes |
| brain-specific angiogenesis inhibitor activity, IEA | 2 genes |
| beta-adrenergic-receptor kinase activity, IEA | 2 genes |
| barbed-end actin filament capping, TAS | 2 genes |
| Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and pfam00768 D-alanyl-D-alanine carboxypeptidase | 1 genes |
| Bac_DnaA, Bacterial dnaA protein | 1 genes |
| BRCA2, BRCA2 repeat. The alignment covers only the most conserved region of the repeat | 1 genes |
| Bac_surface_Ag, Surface antigen. This entry includes the following surface antigens; D15 antigen from H.influenzae, OMA87 from P.multocida, OMP85 from N.meningitidis and N.gonorrhoeae. The family also includes a number of eukaryotic proteins a | 1 genes |
| B12-binding_2, B12 binding domain. This B12 binding domain is found in methionine synthase EC:2.1.1.13, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of pfam02310. The structure of this domain is kn | 1 genes |
| BPD_transp_2, Branched-chain amino acid transport system / permease component. This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV- | 1 genes |
| B3_4, B3/4 domain. This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins | 1 genes |
| B5, tRNA synthetase B5 domain. This domain is found in phenylalanine-tRNA synthetase beta subunits | 1 genes |
| Beta-APP, Beta-amyloid peptide (beta-APP) | 1 genes |
| Baculo_p48, Baculovirus P48 protein | 1 genes |
| B-tub_coD, Beta-tubulin cofactor D. Beta-tubulin cofactor D is essential for the folding of tubulin molecules. It also plays a role (along with co-factors C and E) in the assembly of the alpha/beta- tubulin heterodimer and can interact with na | 1 genes |
| Bac_GDH, Bacterial NAD-glutamate dehydrogenase. This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distr | 1 genes |
| Bystin, Bystin. Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary | 1 genes |
| BCAS2, Breast carcinoma amplified sequence 2 (BCAS2). This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins. BCAS2 | 1 genes |
| Barren, Barren protein. This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is pres | 1 genes |
| BRE, Brain and reproductive organ-expressed protein (BRE). This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induce | 1 genes |
| BAMBI, BMP and activin membrane-bound inhibitor (BAMBI). This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF | 1 genes |
| BID, BH3 interacting domain (BID). BID is a member of the BCL-2 superfamily of proteins are key regulators of programmed cell death, hence this family is related to pfam00452 . BID is a pro-apoptotic member of the Bcl-2 superfamily and as such | 1 genes |
| BC10, Bladder cancer-related protein BC10. This family consists of a series of short proteins of around 90 residues in length. The human protein BC10 has been implicated in bladder cancer where the transcription of the gene coding for this pro | 1 genes |
| Bim_N, Bim protein N-terminus. This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, | 1 genes |
| BAALC_N, BAALC N-terminus. This family represents the N-terminal region of the mammalian BAALC proteins. BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organisms. Two isof | 1 genes |
| biological_process unknown, NAS | 1 genes |
| barrier septum formation, IEA | 1 genes |
| beta-amyloid binding, IDA | 1 genes |
| beta-amyloid binding, TAS | 1 genes |
| branching morphogenesis, ISS | 1 genes |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity, TAS | 1 genes |
| beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, IEA | 1 genes |
| beta-carotene 15,15'-monooxygenase activity, IEA | 1 genes |
| beta-galactoside alpha-2,6-sialyltransferase activity, IDA | 1 genes |
| beta-ureidopropionase activity, IEA | 1 genes |
| beta DNA polymerase activity, IEA | 1 genes |
| beta DNA polymerase activity, TAS | 1 genes |
| biotin carboxylase activity, TAS | 1 genes |
| biotin-[acetyl-CoA-carboxylase] ligase activity, IEA | 1 genes |
| biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity, IEA | 1 genes |
| biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity, IEA | 1 genes |
| biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity, TAS | 1 genes |
| bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, ISS | 1 genes |
| bisphosphoglycerate mutase activity, NAS | 1 genes |
| bisphosphoglycerate mutase activity, TAS | 1 genes |
| bisphosphoglycerate phosphatase activity, NAS | 1 genes |
| butyryl-CoA dehydrogenase activity, IEA | 1 genes |
| beta-N-acetylhexosaminidase activity, IEA | 1 genes |
| beta-N-acetylhexosaminidase activity, TAS | 1 genes |
| beta-galactosidase activity, IEA | 1 genes |
| beta-galactosidase activity, TAS | 1 genes |
| beta-mannosidase activity, TAS | 1 genes |
| beta1-adrenergic receptor activity, TAS | 1 genes |
| beta2-adrenergic receptor activity, TAS | 1 genes |
| bombesin receptor activity, IEA | 1 genes |
| basic amino acid permease activity, TAS | 1 genes |
| binding, IDA | 1 genes |
| binding, NAS | 1 genes |
| basement membrane, IDA | 1 genes |
| basement membrane, NAS | 1 genes |
| basal lamina, NAS | 1 genes |
| base-excision repair, NR | 1 genes |
| biogenic amine metabolism, TAS | 1 genes |
| bile acid biosynthesis, NR | 1 genes |
| biotin metabolism, NAS | 1 genes |
| biotin metabolism, NR | 1 genes |
| bilirubin conjugation, TAS | 1 genes |
| binding of sperm to zona pellucida, IEA | 1 genes |
| binding of sperm to zona pellucida, NAS | 1 genes |
| brain development, IDA | 1 genes |
| brain development, IMP | 1 genes |
| behavior, ISS | 1 genes |
| behavior, NR | 1 genes |
| bile acid metabolism, ISS | 1 genes |
| bacterial binding, IDA | 1 genes |
| beta-glucosidase activity, IDA | 1 genes |
| beta-glucosidase activity, ISS | 1 genes |
| bleomycin hydrolase activity, TAS | 1 genes |
| beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity, IDA | 1 genes |
| benzodiazepine receptor activity, NAS | 1 genes |
| bile acid:sodium symporter activity, NAS | 1 genes |
| beta-aspartyl-peptidase activity, TAS | 1 genes |
| bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity, TAS | 1 genes |
| biotin binding, NAS | 1 genes |
| blue light photoreceptor activity, ISS | 1 genes |
| basal plasma membrane, ISS | 1 genes |
| beta3-adrenergic receptor activity, TAS | 1 genes |
| basic amino acid transporter activity, NR | 1 genes |
| bile acid porter activity, TAS | 1 genes |
| basic amino acid transport, TAS | 1 genes |
| basolateral plasma membrane, IDA | 1 genes |
| basolateral plasma membrane, ISS | 1 genes |
| benzoate metabolism, NAS | 1 genes |
| butyrate metabolism, NAS | 1 genes |
| B-cell mediated immunity, TAS | 1 genes |
| benzodiazepine receptor binding, IPI | 1 genes |
| benzodiazepine receptor binding, TAS | 1 genes |
| bone mineralization, ISS | 1 genes |
| beta-2-microglobulin binding, TAS | 1 genes |
| B-cell proliferation, IDA | 1 genes |
| B-cell proliferation, ISS | 1 genes |
| B-cell activation, NAS | 1 genes |
| BRE binding, IDA | 1 genes |
| BRE binding, ISS | 1 genes |
| basal protein localization, ISS | 1 genes |
| basal protein localization, NAS | 1 genes |
| bone resorption, NAS | 1 genes |
| bone resorption, TAS | 1 genes |
| basophil activation, IDA | 1 genes |
| betaine-homocysteine S-methyltransferase activity, ISS | 1 genes |
| beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity, NAS | 1 genes |
| biotinidase activity, IEA | 1 genes |
| bis(5'-adenosyl)-triphosphatase activity, IEA | 1 genes |
| butyrate-CoA ligase activity, IDA | 1 genes |
| beta-amyloid metabolism, IDA | 1 genes |
| beta-amyloid metabolism, ISS | 1 genes |
| brown adipocyte differentiation, ISS | 1 genes |
| body fluid osmoregulation, NAS | 1 genes |
| barbed-end actin filament capping, ISS | 1 genes |
| barbed-end actin filament capping, NAS | 1 genes |
AS3D Human
