AS3D Human


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Human Gene Lists N
nucleus, IEA1702 genes
nucleic acid binding, IEA559 genes
nucleus, TAS467 genes
nucleus, NAS308 genes
neurogenesis, TAS154 genes
negative regulation of cell proliferation, TAS110 genes
nucleotide binding, IEA107 genes
nucleus, IDA83 genes
nucleus, NR77 genes
negative regulation of cell cycle, IEA63 genes
nuclear mRNA splicing, via spliceosome, IEA55 genes
nucleus, ISS55 genes
negative regulation of transcription from Pol II promoter, TAS52 genes
neuropeptide signaling pathway, IEA50 genes
Neur_chan_LBD, Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure48 genes
Neur_chan_memb, Neurotransmitter-gated ion-channel transmembrane region. This family includes the four transmembrane helices that form the ion channel45 genes
Nucleo_P87, Nucleopolyhedrovirus capsid protein P87. This family consists of several Nucleopolyhedrovirus capsid protein P87 sequences. P87 is expressed late in infection and concentrated in infected cell nuclei44 genes
Nop14, Nop14-like family. Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production40 genes
neurogenesis, IEA36 genes
NADH dehydrogenase activity, IEA34 genes
nucleoplasm, TAS34 genes
nucleolus, TAS30 genes
nucleosome assembly, IEA30 genes
NADH dehydrogenase (ubiquinone) activity, TAS30 genes
nucleosome, NAS29 genes
nucleosome assembly, NAS29 genes
NACHT, NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam0093126 genes
nucleosome, IEA26 genes
neurotransmitter receptor activity, IEA26 genes
nucleobase, nucleoside, nucleotide and nucleic acid metabolism, TAS24 genes
Nucleoplasmin, Nucleoplasmin. Nucleoplasmins are also known as chromatin decondensation proteins. They bind to core histones and transfer DNA to them in a reaction that requires ATP. This is thought to play a role in the assembly of regular nu23 genes
Neisseria_TspB, Neisseria meningitidis TspB protein. This family consists of several Neisseria meningitidis TspB virulence factor proteins23 genes
NUDIX, NUDIX domain20 genes
NAP, Nucleosome assembly protein (NAP). It is thought that NAPs may be involve in regulating gene expression as a result of histone accessibility20 genes
nuclear pore, TAS20 genes
neurotransmitter transport, IEA20 genes
nucleotide metabolism, IEA19 genes
NTR, NTR/C345C module. We have not included the related pfam00965 family. It has been suggested that the common function of these modules is binding to metzincins. A subset of this family is known as the C345C domain because it occurs in compl18 genes
neurogenesis, NAS18 genes
Na_H_Exchanger, Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regio17 genes
NPIP, Nuclear pore complex interacting protein (NPIP). This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African ap17 genes
nucleus, IC16 genes
NAD_binding_1, Oxidoreductase NAD-binding domain. Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity14 genes
negative regulation of adenylate cyclase activity, TAS14 genes
NAC, NAC domain13 genes
NOA36, NOA36 protein. This family consists of several NOA36 proteins which contain 29 highly conserved cysteine residues. The function of this protein is unknown13 genes
nucleus, IEP13 genes
N-linked glycosylation, TAS13 genes
neurogenesis, NR13 genes
N-acetyltransferase activity, IEA13 genes
negative regulation of transcription, NAS13 genes
NDK, Nucleoside diphosphate kinase12 genes
nuclear membrane, TAS12 genes
nucleobase, nucleoside, nucleotide and nucleic acid metabolism, IEA12 genes
nucleoside metabolism, IEA12 genes
nucleotidyltransferase activity, IEA12 genes
Na_trans_assoc, Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four c11 genes
nicotinic acetylcholine-gated receptor-channel complex, TAS11 genes
NLS-bearing substrate-nucleus import, TAS11 genes
non-membrane spanning protein tyrosine kinase activity, TAS10 genes
nicotinic acetylcholine-activated cation-selective channel activity, TAS10 genes
neuropeptide hormone activity, TAS10 genes
nitrogen metabolism, IEA10 genes
negative regulation of cell growth, NAS10 genes
Na_Ca_ex, Sodium/calcium exchanger protein. This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concen9 genes
NTF2, Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins9 genes
nucleotide binding, TAS9 genes
nuclear pore, IEA9 genes
N-linked glycosylation, IEA9 genes
negative regulation of cell proliferation, NAS9 genes
nucleotide biosynthesis, IEA9 genes
natural killer cell activation, NAS9 genes
Nol1_Nop2_Sun, NOL1/NOP2/sun family8 genes
Nucleoside_tran, Nucleoside transporter. This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathway8 genes
nuclear mRNA splicing, via spliceosome, NAS8 genes
neurotransmitter:sodium symporter activity, IEA8 genes
nucleotide-excision repair, TAS8 genes
neuropeptide signaling pathway, TAS8 genes
NHL, NHL repeat. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats may have a catalytic activity, proteolysis of one menber has shown tha7 genes
NIF, NLI interacting factor-like phosphatase. This family contains a number of NLI interacting factor isoforms and also an N-terminal regions of RNA polymerase II CTC phosphatase and FCP1 serine phosphatase. This region has been identified as 7 genes
neprilysin activity, IEA7 genes
nitric oxide biosynthesis, TAS7 genes
neuropeptide signaling pathway, NAS7 genes
neurogenesis, ISS7 genes
negative regulation of transcription, IDA7 genes
negative regulation of transcription, IEA7 genes
negative regulation of cell growth, IDA7 genes
nutrient reservoir activity, IEA7 genes
Na_sulph_symp, Sodium:sulfate symporter transmembrane region. There are also some members in this family, which belong to the subfamily SODIT16 genes
NTP_transf_2, Nucleotidyltransferase domain. Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types 6 genes
Nuc_sug_transp, Nucleotide-sugar transporter. This family of membrane proteins transport nucleotide sugars from the cytoplasm into golgi vesicles. Members transport CMP-sialic acid, UDP-galactose and UDP-GlcNAc, for example6 genes
NC, NC domain. Members of this family are characterised by containing a well conserved NCEHF motif. The role of this domain is unclear6 genes
nucleoside-diphosphate kinase activity, IEA6 genes
non-membrane spanning protein tyrosine phosphatase activity, TAS6 genes
nicotinic acetylcholine-activated cation-selective channel activity, IEA6 genes
non-G-protein coupled 7TM receptor activity, IEA6 genes
neuropeptide Y receptor activity, IEA6 genes
nucleoplasm, IDA6 genes
nucleolus, ISS6 genes
N-glycan processing, TAS6 genes
neurotransmitter secretion, TAS6 genes
negative regulation of cell growth, ISS6 genes
neurotransmitter catabolism, IEA6 genes
negative regulation of transcription, DNA-dependent, IDA6 genes
Notch, Notch (DSL) domain. The Notch domain is also called the 'DSL' domain. The notch proteins are transmembrane proteins with extracellular domains of repeated EGF domains and the notch (or DSL) domain N-terminal to that. These proteins are 5 genes
Na_K-ATPase, Sodium / potassium ATPase beta chain5 genes
Ndr, Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, 5 genes
Neurexophilin, Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed af5 genes
nuclear chromosome, NAS5 genes
nuclear chromosome, TAS5 genes
nuclease activity, IEA5 genes
nucleolus, IDA5 genes
nucleosome assembly, TAS5 genes
negative regulation of cell adhesion, TAS5 genes
nitric oxide mediated signal transduction, TAS5 genes
nuclear localization sequence binding, TAS5 genes
negative regulation of protein biosynthesis, IEA5 genes
negative regulation of coagulation, IEA5 genes
NGF, Nerve growth factor family4 genes
NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase4 genes
NNMT_PNMT_TEMT, NNMT/PNMT/TEMT family4 genes
Nop, Putative snoRNA binding domain. This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yea4 genes
Nuclear_move, Nuclear movement protein. The nuclear movement protein or NudC, was first identified as a nuclear distribution (nud) gene that regulates nuclear movement in the filamentous fungus. The mammalian homologue of NudC interacts with L4 genes
Not3, Not1 N-terminal domain, CCR4-Not complex component4 genes
NisC, NisC-like family. Lantibiotics are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. Lantibiotic peptides contain thioether bridges termed lanthionines that are putatively generated by d4 genes
NESP55, Neuroendocrine-specific golgi protein P55 (NESP55). This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, h4 genes
Neugrin, Neugrin. This family consists of several mouse and human neugrin proteins. Neugrin and m-neugrin are mainly expressed in neurons in the nervous system, and are thought to play an important role in the process of neuronal differentiati4 genes
Neogenin_C, Neogenin C-terminus. This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and 4 genes
NOD, NOTCH protein. NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD (NOTCH protein domain) represents a region present in many NOTCH proteins and NOTCH homologs in multip4 genes
Neuralized, Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch p4 genes
negative regulation of transcription from Pol II promoter, IDA4 genes
nuclear mRNA splicing, via spliceosome, IDA4 genes
N-acetyllactosamine synthase activity, IEA4 genes
NAD+ ADP-ribosyltransferase activity, TAS4 genes
nucleoside-diphosphate kinase activity, TAS4 genes
neuropeptide hormone activity, IEA4 genes
nucleotide-sugar transporter activity, IEA4 genes
nucleolar ribonuclease P complex, TAS4 genes
nucleolus, NAS4 genes
nucleotide-excision repair, IEA4 genes
negative regulation of cell adhesion, NAS4 genes
Notch signaling pathway, ISS4 genes
neuronal cell recognition, TAS4 genes
NADH dehydrogenase (ubiquinone) activity, IEA4 genes
N-methyltransferase activity, IEA4 genes
neuropeptide receptor activity, NAS4 genes
negative regulation of survival gene product activity, TAS4 genes
N-acetylmuramoyl-L-alanine amidase activity, IEA4 genes
neutral amino acid transporter activity, TAS4 genes
nucleotide-sugar transport, IEA4 genes
negative regulation of transcription, ISS4 genes
negative regulation of blood coagulation, IEA4 genes
negative regulation of myogenesis, TAS4 genes
negative regulation of transcription, DNA-dependent, ISS4 genes
NTP_transferase, Nucleotidyl transferase. This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars3 genes
Nebulin, Nebulin repeat3 genes
Nucleoside_tra2, Na+ dependent nucleoside transporter. This family consists of nucleoside transport proteins. One member is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane. One member is a a Na+-depend3 genes
Na_Pi_cotrans, Na+/Pi-cotransporter. This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type 3 genes
NO_synthase, Nitric oxide synthase, oxygenase domain3 genes
NAD_binding_2, NAD binding domain of 6-phosphogluconate dehydrogenase. The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossman fold3 genes
NAPRTase, Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also includes Pre-B ce3 genes
NodS, Nodulation protein S (NodS). This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal mole3 genes
nuclear chromosome, IEA3 genes
nucleic acid binding, TAS3 genes
NAD+ ADP-ribosyltransferase activity, IEA3 genes
NAD(P)+-protein-arginine ADP-ribosyltransferase activity, IEA3 genes
nucleotide diphosphatase activity, TAS3 genes
N-formyl peptide receptor activity, IEA3 genes
N-formyl peptide receptor activity, TAS3 genes
neuropeptide Y receptor activity, TAS3 genes
nucleoside transporter activity, TAS3 genes
nucleoside:sodium symporter activity, IEA3 genes
nucleocytoplasmic transporter activity, IDA3 genes
nuclear membrane, IDA3 genes
nuclear membrane, ISS3 genes
nuclear outer membrane, TAS3 genes
nuclear pore, NAS3 genes
neurofilament, NAS3 genes
neurofilament, TAS3 genes
N-acetylglucosamine metabolism, IEA3 genes
nucleobase, nucleoside, nucleotide and nucleic acid metabolism, NR3 genes
nucleosome disassembly, TAS3 genes
N-linked glycosylation, NAS3 genes
nitric oxide biosynthesis, IEA3 genes
neurotransmitter transport, NAS3 genes
negative regulation of cell adhesion, IDA3 genes
Notch signaling pathway, NAS3 genes
neurotransmitter secretion, IEA3 genes
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity, TAS3 genes
negative regulation of DNA replication, TAS3 genes
negative regulation of cell proliferation, IDA3 genes
negative regulation of cell proliferation, ISS3 genes
nucleoside triphosphate biosynthesis, NAS3 genes
nucleotide-sugar metabolism, IEA3 genes
nitrogen fixation, IEA3 genes
nucleoside transport, TAS3 genes
nuclear matrix, IDA3 genes
negative regulation of angiogenesis, IDA3 genes
nuclear body, IDA3 genes
natriuresis, TAS3 genes
negative regulation of Wnt receptor signaling pathway, IEA3 genes
neuron differentiation, NAS3 genes
neutrophil chemotaxis, IDA3 genes
neurotransmitter metabolism, TAS3 genes
neurotransmitter biosynthesis, IEA3 genes
neurotrophin binding, TAS3 genes
negative regulation of translational initiation, IEA3 genes
negative regulation of follicle-stimulating hormone secretion, NAS3 genes
NMT, Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain. The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold2 genes
NAD_kinase, ATP-NAD kinase. Members of this family are ATP-NAD kinases EC:2.7.1.23. Catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus2 genes
Nramp, Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related2 genes
Neuregulin, Neuregulin family2 genes
NMT_C, Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain. The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold2 genes
NPD, 2-nitropropane dioxygenase. Members of this family catalyse the denitrification of a number of nitroalkanes using either FAD or FMN as a cofactor2 genes
Nucleoporin, Non-repetitive/WGA-negative nucleoporin. This is a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especi2 genes
Nuc_H_symport, Nucleoside H+ symporter2 genes
NOT2_3_5, NOT2 / NOT3 / NOT5 family. NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT52 genes
NUDE_C, NUDE protein, C-terminal conserved region. This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration2 genes
NCD1, NAB conserved region 1 (NCD1). Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region co2 genes
NCD2, NAB conserved region 2 (NCD2). Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family co2 genes
Ninjurin, Ninjurin. Ninjurin (nerve injury-induced protein) is involved in nerve regeneration and in the formation and function in some tissues2 genes
Nsp1_C, Nsp1-like C-terminal region. This family probably forms a coiled-coil. This important region of Nsp1 is involved in binding Nup822 genes
Nicastrin, Nicastrin. Nicastrin and presenilin are two major components of the gamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Ni2 genes
Nop52, Nucleolar protein,Nop52. Nop52 believed to be involved in the generation of 28S rRNA2 genes
NPR2, Nitrogen permease regulator 2. This family of regulators are involved in post-translational control of nitrogen permease2 genes
NumbF, NUMB phenylalanine-rich region. This domain is in the Numb family of proteins2 genes
NT5C, 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C). This family consists of several 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C (NT5C) proteins. 5'(3')-Deoxyribonucleotidase is a ubiquitous enzyme in mammalian2 genes
NID, Nmi/IFP 35 domain (NID). This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi prot2 genes
negative regulation of transcription from Pol II promoter, NR2 genes
nicotinamide-nucleotide adenylyltransferase activity, IEA2 genes
nucleosome, ISS2 genes
nuclear chromatin, IDA2 genes
neurotransmitter uptake, TAS2 genes
N-acetylgalactosamine 4-O-sulfotransferase activity, IDA2 genes
N-acetylgalactosamine 4-O-sulfotransferase activity, ISS2 genes
N-acetylgalactosamine 4-O-sulfotransferase activity, NAS2 genes
neuromedin U receptor activity, IDA2 genes
nucleic acid binding, NAS2 genes
NAD+ nucleosidase activity, IEA2 genes
NADH dehydrogenase activity, NAS2 genes
NADPH:quinone reductase activity, IEA2 genes
nicotinate phosphoribosyltransferase activity, IEA2 genes
nitric-oxide synthase activity, TAS2 genes
nuclease activity, TAS2 genes
NF-kappaB-inducing kinase activity, TAS2 genes
N-methyl-D-aspartate selective glutamate receptor activity, TAS2 genes
Notch binding, NAS2 genes
neuropeptide hormone activity, NR2 genes
neurohypophyseal hormone activity, IEA2 genes
nucleoside transporter activity, IEA2 genes
nucleocytoplasmic transporter activity, NAS2 genes
nuclear membrane, IEA2 genes
nuclear membrane, NAS2 genes
nuclear pore, IDA2 genes
nuclear heterochromatin, TAS2 genes
nucleolus, NR2 genes
non-muscle myosin, TAS2 genes
nucleotide-excision repair, NAS2 genes
nucleotide-excision repair, NR2 genes
nucleosome assembly, ISS2 genes
negative regulation of protein kinase activity, IEA2 genes
negative regulation of protein kinase activity, TAS2 genes
N-terminal protein myristoylation, IEA2 genes
nucleocytoplasmic transport, ISS2 genes
nuclear organization and biogenesis, TAS2 genes
neuronal cell adhesion, NAS2 genes
neuronal cell adhesion, TAS2 genes
neurotransmitter secretion, NAS2 genes
neuromuscular junction development, TAS2 genes
N-acetyltransferase activity, TAS2 genes
NADH dehydrogenase (ubiquinone) activity, NAS2 genes
NADH dehydrogenase (ubiquinone) activity, NR2 genes
neuropeptide receptor activity, TAS2 genes
nerve ensheathment, NAS2 genes
nerve ensheathment, TAS2 genes
nucleoside metabolism, TAS2 genes
nucleotide metabolism, TAS2 genes
NAD biosynthesis, IEA2 genes
negative regulation of signal transduction, NAS2 genes
neutral amino acid transport, TAS2 genes
nuclear matrix, NAS2 genes
negative regulation of translation, ISS2 genes
neurotensin receptor activity, G-protein coupled, IEA2 genes
negative regulation of angiogenesis, TAS2 genes
nucleotidyltransferase activity, ISS2 genes
nucleoside-diphosphatase activity, IEA2 genes
negative regulation of protein biosynthesis, IDA2 genes
negative regulation of protein biosynthesis, ISS2 genes
N-linked glycosylation via asparagine, IEA2 genes
negative regulation of Wnt receptor signaling pathway, ISS2 genes
negative regulation of Wnt receptor signaling pathway, NAS2 genes
neuron differentiation, TAS2 genes
negative regulation of bone mineralization, ISS2 genes
negative regulation of bone mineralization, NAS2 genes
neurexin binding, ISS2 genes
neutrophil activation, TAS2 genes
neurotransmitter metabolism, NR2 genes
natural killer cell mediated cytolysis, ISS2 genes
natural killer cell mediated cytolysis, NAS2 genes
negative regulation of phosphorylation, TAS2 genes
negative regulation of tyrosine phosphorylation of Stat3 protein, ISS2 genes
negative regulation of tyrosine phosphorylation of Stat3 protein, NAS2 genes
neuronal Cdc2-like kinase binding, NAS2 genes
neuronal cell projection, NAS2 genes
negative regulation of interferon-gamma biosynthesis, TAS2 genes
negative regulation of B-cell differentiation, TAS2 genes
negative regulation of macrophage differentiation, TAS2 genes
negative regulation of osteoclast differentiation, NAS2 genes
negative regulation of S phase of mitotic cell cycle, ISS2 genes
negative regulation of cell cycle, ISS2 genes
negative regulation of cell cycle, NAS2 genes
negative regulation of cell cycle, TAS2 genes
negative regulation of transcription, DNA-dependent, NAS2 genes
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity, IEA2 genes
NADPH binding, NAS2 genes
Nitroreductase, Nitroreductase family. Members of this family utilise FMN as a cofactor1 genes
NB-ARC, NB-ARC domain1 genes
NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown1 genes
NifU_N, NifU-like N terminal domain. This domain is found in NifU in combination with pfam01106. This domain is found on isolated proteins in several bacterial species. The nif genes are responsible for nitrogen fixation. However this domain i1 genes
NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologues. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of1 genes
NMU, Neuromedin U1 genes
NAD_synthase, NAD synthase. NAD synthase (EC:6.3.5.1) is involved in the de novo synthesis of NAD and is induced by stress factors such as heat shock and glucose limitation1 genes
NeuB, NeuB family. NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This1 genes
NtA, Agrin NtA domain. Agrin is a multidomain heparan sulphate proteoglycan, that is a key organiser for the induction of postsynaptic specialisations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino ter1 genes
Nuf2, Nuf2 family. Members of this family are components of the mitotic spindle. It has been shown that Nuf2 from yeast is part of a complex called the Ndc80p complex. This complex is thought to bind to the microtubules of the spindle. An arab1 genes
Ndc80_HEC, HEC/Ndc80p family. Members of this family are components of the mitotic spindle. It has been shown that Ndc80/HEC from yeast is part of a complex called the Ndc80p complex. This complex is thought to bind to the microtubules of the 1 genes
Nrap, Nrap protein. Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in th1 genes
Neurokinin_B, Neurokinin B1 genes
Nup133, Nup133 nucleoporin. RNA undergoing nuclear export first encounters the basket of the nuclear pore. Nup133 is a nucleoporin accessible on the basket side of the pore1 genes
Not1, CCR4-Not complex component, Not1. The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID1 genes
Nucleoporin2, Nucleoporin autopeptidase1 genes
NIC, Nucleoporin interacting component1 genes
Nup84_Nup100, Nuclear pore protein 84 / 107. Nup84p forms a complex with five proteins, of which Nup120p, Nup85p, Sec13p, and a Sec13p homologues. This Nup84p complex in conjunction with Sec13-type proteins is required for correct nuclear pore1 genes
Nop10p, Nucleolar RNA-binding protein, Nop10p family. Nop10p is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particle1 genes
Nin1_C, 26S proteasome non-ATPase regulatory subunit Nin1/mts3. The 26S protease (or 26S proteasome) is responsible for degrading ubiquitin conjugates. It consists of 19S regulatory complexes associated with the ends of 20S proteasomes. The 191 genes
Nab1, Conserved region in Nab1. Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This C-terminal reg1 genes
NMD3, NMD3 family. The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by1 genes
Nuc_deoxyrib_tr, Nucleoside 2-deoxyribosyltransferase. Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides1 genes
NPL4, NPL4 family. The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characteri1 genes
NosD, Periplasmic copper-binding protein (NosD). NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ)1 genes
NAGLU, Alpha-N-acetylglucosaminidase (NAGLU). Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharid1 genes
NmrA, NmrA-like family. NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi. This family on1 genes
NAF1, NAF1 domain. This domain is involved in snoRNP biogenesis1 genes
Neurochondrin, Neurochondrin. This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast1 genes
NDUF_B7, NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7). This family consists of several NADH-ubiquinone oxidoreductase B18 subunit proteins from different eukaryotic organisms. Oxidative phosphorylation is the well-characterised process 1 genes
Noggin, Noggin. This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that n1 genes
NDUF_B8, NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8). This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely com1 genes
NDUF_C2, NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2). This family consists of several NADH-ubiquinone oxidoreductase subunit b14.5b proteins (EC:1.6.5.3)1 genes
NADH_dehy_S2_C, NADH dehydrogenase subunit 2 C-terminus. This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam003611 genes
Neural_ProG_Cyt, Neural chondroitin sulphate proteoglycan cytoplasmic domain. This family represents the C-terminal cytoplasmic domain of vertebrate neural chondroitin sulphate proteoglycans that contain EGF modules. Evidence has been accumula1 genes
NRIF3, Nuclear receptor co-activator NRIF3. This family consists of mammalian nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs b1 genes
NPDC1, Neural proliferation differentiation control-1 protein (NPDC1). This family consists of several neural proliferation differentiation control-1 (NPDC1) proteins. NPDC1 plays a role in the control of neural cell proliferation and differen1 genes
NOG1, Nucleolar GTP-binding protein 1 (NOG1). This family represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). In S. cerevisiae, the NOG1 gene has been shown to be essential for ce1 genes
NDUF_B4, NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4). This family consists of several NADH-ubiquinone oxidoreductase B15 subunit proteins (EC:1.6.5.3)1 genes
NICE-3, NICE-3 protein. This family consists of several eukaryotic NICE-3 and related proteins. The gene coding for NICE-3 is part of the epidermal differentiation complex (EDC) which comprises a large number of genes that are of crucial impor1 genes
negative regulation of transcription from Pol II promoter, ISS1 genes
nucleotide binding, NAS1 genes
nuclear exosome (RNase complex), IDA1 genes
nuclear exosome (RNase complex), IEP1 genes
nuclear exosome (RNase complex), NAS1 genes
N-acetylglucosaminylphosphatidylinositol deacetylase activity, NAS1 genes
nitrilase activity, TAS1 genes
nuclear division, IEA1 genes
nicotinamide-nucleotide adenylyltransferase activity, IDA1 genes
nuclear mRNA 5'-splice site recognition, IDA1 genes
nucleosome, IDA1 genes
nucleosome, TAS1 genes
nuclear chromatin, ISS1 genes
neurotransmitter uptake, NR1 genes
N-acetylglucosamine 6-O-sulfotransferase activity, TAS1 genes
neuronal migration, NAS1 genes
N-acetyl-gamma-glutamyl-phosphate reductase activity, NR1 genes
N-acetylgalactosamine-4-sulfatase activity, IEA1 genes
N-acetylgalactosamine-4-sulfatase activity, TAS1 genes
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity, TAS1 genes
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity, TAS1 genes
NAD+ ADP-ribosyltransferase activity, IDA1 genes
NAD+ ADP-ribosyltransferase activity, NAS1 genes
NAD+ kinase activity, IDA1 genes
NAD+ kinase activity, ISS1 genes
NAD+ synthase (glutamine-hydrolyzing) activity, IEA1 genes
NAD(P)H dehydrogenase (quinone) activity, IEA1 genes
NAD(P)H dehydrogenase (quinone) activity, TAS1 genes
NAD(P)+-protein-arginine ADP-ribosyltransferase activity, NAS1 genes
NAD(P)+ transhydrogenase (B-specific) activity, TAS1 genes
NADPH:quinone reductase activity, TAS1 genes
nicotinate-nucleotide diphosphorylase (carboxylating) activity, TAS1 genes
nitric-oxide synthase activity, ISS1 genes
nitric-oxide synthase activity, NR1 genes
nucleoside-diphosphate kinase activity, NAS1 genes
NF-kappaB-inducing kinase activity, IDA1 genes
non-membrane spanning protein tyrosine kinase activity, IDA1 genes
non-membrane spanning protein tyrosine kinase activity, NAS1 genes
non-membrane spanning protein tyrosine phosphatase activity, IEA1 genes
non-membrane spanning protein tyrosine phosphatase activity, NR1 genes
nicotinic acetylcholine-activated cation-selective channel activity, NAS1 genes
N-methyl-D-aspartate selective glutamate receptor activity, ISS1 genes
N-methyl-D-aspartate selective glutamate receptor activity, NAS1 genes
N-methyl-D-aspartate selective glutamate receptor activity, NR1 genes
netrin receptor activity, TAS1 genes
nuclear export signal receptor activity, IDA1 genes
nuclear export signal receptor activity, TAS1 genes
Notch binding, IDA1 genes
Notch binding, IPI1 genes
Notch binding, TAS1 genes
neuropeptide hormone activity, ISS1 genes
neuropeptide hormone activity, NAS1 genes
neurotransmitter transporter activity, TAS1 genes
noradrenaline:sodium symporter activity, TAS1 genes
nucleotide-sugar transporter activity, NAS1 genes
nucleocytoplasmic transporter activity, IEA1 genes
nucleus, IMP1 genes
nuclear inner membrane, NAS1 genes
nuclear inner membrane, TAS1 genes
nuclear pore, ISS1 genes
nuclear pore, NR1 genes
nuclear lamina, NAS1 genes
nuclear lamina, TAS1 genes
nucleoplasm, IMP1 genes
nucleoplasm, ISS1 genes
nucleoplasm, NAS1 genes
nucleoplasm, NR1 genes
nucleolar ribonuclease P complex, IDA1 genes
nuclear origin of replication recognition complex, IEA1 genes
nuclear origin of replication recognition complex, TAS1 genes
nuclear telomeric heterochromatin, NAS1 genes
nucleolus, IEP1 genes
nucleolus organizer complex, NAS1 genes
nascent polypeptide-associated complex, TAS1 genes
nicotinic acetylcholine-gated receptor-channel complex, IC1 genes
N-acetylglucosamine metabolism, IC1 genes
N-acetylglucosamine metabolism, TAS1 genes
N-acetylmannosamine metabolism, TAS1 genes
N-acetylneuraminate metabolism, TAS1 genes
nucleotide-excision repair, IDA1 genes
nucleotide-excision repair, IMP1 genes
nucleotide-excision repair, DNA incision, 5'-to lesion, IDA1 genes
nucleosome disassembly, IMP1 genes
nascent polypeptide association, TAS1 genes
negative regulation of protein kinase activity, ISS1 genes
negative regulation of protein kinase activity, NAS1 genes
N-linked glycosylation, IMP1 genes
N-linked glycosylation, ISS1 genes
N-linked glycosylation, NR1 genes
NADH biosynthesis, IDA1 genes
NADPH metabolism, NAS1 genes
nitrogen metabolism, NAS1 genes
neurotransmitter transport, ISS1 genes
nucleocytoplasmic transport, IEA1 genes
nuclear organization and biogenesis, NAS1 genes
nuclear migration, TAS1 genes
negative regulation of epidermal growth factor receptor activity, NAS1 genes
neuropeptide signaling pathway, ISS1 genes
neuropeptide signaling pathway, NR1 genes
Notch receptor processing, ISS1 genes
nerve-nerve synaptic transmission, ISS1 genes
nerve-nerve synaptic transmission, NAS1 genes
neuromuscular synaptic transmission, ISS1 genes
neuromuscular synaptic transmission, TAS1 genes
neurogenesis, IDA1 genes
neurogenesis, IEP1 genes
neurogenesis, IMP1 genes
neuroblast proliferation, TAS1 genes
neuromuscular junction development, NR1 genes
neuronal cell recognition, NAS1 genes
nicotinamide N-methyltransferase activity, TAS1 genes
N-acetyllactosaminide alpha-2,3-sialyltransferase activity, TAS1 genes
neutrophil collagenase activity, TAS1 genes
NADH dehydrogenase (ubiquinone) activity, IDA1 genes
nuclear localization sequence binding, NR1 genes
negative transcription elongation factor activity, IDA1 genes
negative regulation of DNA replication, IDA1 genes
N-methyltransferase activity, TAS1 genes
neuropeptide receptor activity, IDA1 genes
neuropeptide receptor activity, IEA1 genes
necrosis, IMP1 genes
necrosis, NR1 genes
nucleotidase activity, TAS1 genes
negative regulation of cell proliferation, NR1 genes
N-acetylglucosamine-6-phosphate deacetylase activity, IEA1 genes
N-acetylglucosamine-6-sulfatase activity, TAS1 genes
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, NAS1 genes
NAD(P) transhydrogenase activity, TAS1 genes
NAD(P)+ transhydrogenase (AB-specific) activity, IEA1 genes
NADPH dehydrogenase (quinone) activity, TAS1 genes
N-acylneuraminate cytidylyltransferase activity, IEA1 genes
N-acylneuraminate cytidylyltransferase activity, NAS1 genes
nucleoside metabolism, NAS1 genes
nucleotide metabolism, NAS1 genes
nucleotide biosynthesis, NAS1 genes
nucleotide catabolism, IEA1 genes
nucleotide catabolism, NAS1 genes
nucleotide-sugar metabolism, TAS1 genes
N-acylmannosamine kinase activity, TAS1 genes
neutral amino acid transporter activity, NAS1 genes
nonselective cation channel activity, NAS1 genes
nonselective cation channel activity, TAS1 genes
neutral amino acid transport, IDA1 genes
neutral amino acid transport, NAS1 genes
nickel ion binding, IEA1 genes
NAD(P)H oxidase activity, ISS1 genes
NAD(P)H oxidase activity, NAS1 genes
non-selenium glutathione peroxidase activity, IDA1 genes
N-sulfoglucosamine sulfohydrolase activity, IEA1 genes
neuronal remodeling, IDA1 genes
nuclear matrix, ISS1 genes
negative regulation of transcription, IC1 genes
neurotensin receptor activity, G-protein coupled, NAS1 genes
negative regulation of angiogenesis, NAS1 genes
NuRD complex, IDA1 genes
NuRD complex, ISS1 genes
nardilysin activity, IEA1 genes
N-methyl-D-aspartate selective glutamate receptor complex, IDA1 genes
N-methyl-D-aspartate selective glutamate receptor complex, ISS1 genes
negative regulator of basal transcription activity, IDA1 genes
nucleotide kinase activity, IDA1 genes
negative regulation of anti-apoptosis, IMP1 genes
natural killer cell activation, IDA1 genes
negative regulation of natural killer cell activity, NAS1 genes
neuron differentiation, ISS1 genes
negative regulation of blood coagulation, IDA1 genes
negative regulation of blood coagulation, TAS1 genes
nitric-oxide synthase regulator activity, IDA1 genes
nitric-oxide synthase regulator activity, ISS1 genes
nitric-oxide synthase regulator activity, NAS1 genes
negative regulation of ossification, NAS1 genes
negative regulation of cell growth, IMP1 genes
negative regulation of cell migration, ISS1 genes
negative regulation of BMP signaling pathway, TAS1 genes
negative regulation of axon extension, IDA1 genes
neutrophil chemotaxis, IGI1 genes
neutrophil chemotaxis, NAS1 genes
neurotransmitter receptor activity, ISS1 genes
negative regulation of cGMP biosynthesis, TAS1 genes
negative regulation of cytokine biosynthesis, NAS1 genes
neurexin binding, NAS1 genes
neuronal lineage restriction, IDA1 genes
neuronal lineage restriction, ISS1 genes
neutrophil activation, IDA1 genes
neutrophil activation, NAS1 genes
negative regulation of T-cell proliferation, NAS1 genes
negative regulation of T-cell proliferation, TAS1 genes
negative regulation of protein catabolism, IMP1 genes
negative regulation of protein catabolism, NAS1 genes
nuclear RNA export factor complex, IDA1 genes
nuclear RNA export factor complex, NAS1 genes
NLS-dependent protein nuclear import complex, ISS1 genes
nucleosome mobilization, ISS1 genes
neuronal Cdc2-like kinase binding, IPI1 genes
negative regulation of amyloid precursor protein biosynthesis, IMP1 genes
negative regulation of amyloid precursor protein biosynthesis, ISS1 genes
neuronal cell projection, IDA1 genes
negative regulation of macrophage activation, NAS1 genes
negative regulation of apoptosis, IDA1 genes
negative regulation of apoptosis, IEA1 genes
negative regulation of apoptosis, IMP1 genes
negative regulation of apoptosis, ISS1 genes
negative regulation of non-apoptotic programmed cell death, NAS1 genes
negative regulation of I-kappaB kinase/NF-kappaB cascade, IDA1 genes
negative regulation of nitric oxide biosynthesis, ISS1 genes
negative regulation of viral genome replication, TAS1 genes
negative regulation of interferon-gamma biosynthesis, ISS1 genes
negative regulation of interleukin-2 biosynthesis, TAS1 genes
N-acetylglucosamine kinase activity, IEA1 genes
neurotransmitter receptor biosynthesis, ISS1 genes
negative regulation of MHC class II biosynthesis, TAS1 genes
negative regulation of interferon-alpha biosynthesis, NAS1 genes
negative regulation of cholesterol biosynthesis, NAS1 genes
negative regulation of cell differentiation, IEA1 genes
negative regulation of endothelial cell differentiation, ISS1 genes
negative regulation of T-helper 2 cell differentiation, ISS1 genes
negative regulation of megakaryocyte differentiation, IDA1 genes
negative regulation of neuron differentiation, IGI1 genes
negative regulation of osteoblast differentiation, IDA1 genes
negative regulation of osteoclast differentiation, IDA1 genes
negative regulation of cyclin dependent protein kinase activity, IDA1 genes
negative regulation of S phase of mitotic cell cycle, NAS1 genes
negative regulation of endocytosis, ISS1 genes
negative regulation of mitosis, ISS1 genes
negative regulation of proteolysis and peptidolysis, TAS1 genes
negative regulation of sister chromatid cohesion, NAS1 genes
negative regulation of transcription, DNA-dependent, IEP1 genes
negative regulation of transcription, DNA-dependent, IMP1 genes
negative regulation of translational elongation, IEA1 genes
negative regulation of growth, ISS1 genes
negative regulation of nucleoside metabolism, IEA1 genes
negative regulation of translational initiation by iron, NAS1 genes
negative regulation of glucosylceramide biosynthesis, NAS1 genes
negative regulation of glucose import, IDA1 genes
negative regulation of JNK cascade, IDA1 genes
negative regulation of JNK cascade, TAS1 genes
negative regulation of JAK-STAT cascade, NAS1 genes
negative regulation of calcium-dependent cell-cell adhesion, NAS1 genes
negative regulation of virion penetration, NAS1 genes
negative regulation of centriole replication, NAS1 genes
negative regulation of insulin receptor signaling pathway, NAS1 genes
negative regulation of insulin secretion, IDA1 genes
negative regulation of follicle-stimulating hormone secretion, IPI1 genes
nucleoside-triphosphate-adenylate kinase activity, IEA1 genes
negative regulation of hemoglobin biosynthesis, ISS1 genes
nucleoside-triphosphate diphosphatase activity, IEA1 genes
N-acylneuraminate-9-phosphate synthase activity, IEA1 genes
negative regulation of nuclear mRNA splicing, via spliceosome, IDA1 genes
negative regulation of hepatocyte growth factor biosynthesis, IDA1 genes
N-acylglucosamine 2-epimerase activity, IEA1 genes
N-acetylneuraminate synthase activity, IEA1 genes
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity, IDA1 genes
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity, ISS1 genes
NADPH binding, IDA1 genes
NADPH binding, ISS1 genes
negative regulation of lymphocyte proliferation, IDA1 genes
negative regulation of inflammatory response, NAS1 genes
negative regulation of lipoprotein metabolism, NAS1 genes
negative regulation of thymidylate synthase biosynthesis, ISS1 genes
negative regulation of dendrite morphogenesis, ISS1 genes
negative regulation of immune response, NAS1 genes
negative regulation of coagulation, IDA1 genes
negative regulation of calcium-mediated signaling, IDA1 genes
negative regulation of B-cell activation, TAS1 genes
negative regulation of lipid catabolism, NAS1 genes
negative regulation of lipoprotein lipase activity, ISS1 genes
AS3D: Alternative Splicing Structural Genomics Projects
CARB/UMBI