AS3D Human


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Human Gene Lists L
ligase activity, IEA123 genes
lyase activity, IEA96 genes
Lectin_C, Lectin C-type domain. This family includes both long and short form C-type85 genes
lipid metabolism, TAS76 genes
LIM, LIM domain. This family represents two copies of the LIM structural domain74 genes
lipid binding, IEA59 genes
lipid catabolism, IEA46 genes
Ldl_recept_a, Low-density lipoprotein receptor domain class A43 genes
Laminin_G, Laminin G domain42 genes
lipid transport, IEA41 genes
Lipocalin, Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. Alignment subsumes both lipocalin and fatty acid binding 35 genes
lysosome, TAS32 genes
Laminin_EGF, Laminin EGF-like (Domains III and V). This family is like pfam00008 but has 8 conserved cysteines instead of 629 genes
Laminin_I, Laminin Domain I. coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure29 genes
lipid metabolism, IEA28 genes
lysosome, IEA25 genes
LSM, LSM domain. The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D22 genes
lysosome, NR21 genes
Lig_chan, Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors18 genes
Laminin_N, Laminin N-terminal (Domain VI)17 genes
LISCH7, LISCH7. This family consists of mammalian LISCH7 protein homologues. LISCH7 is a liver-specific BHLH-ZIP transcription factor16 genes
lipid metabolism, NR16 genes
Ldl_recept_b, Low-density lipoprotein receptor repeat class B. This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta15 genes
Lactamase_B, Metallo-beta-lactamase superfamily15 genes
LBP_BPI_CETP, LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar13 genes
lipid transporter activity, IEA13 genes
lipoprotein metabolism, IEA12 genes
Linker_histone, linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types11 genes
lipid transporter activity, TAS11 genes
leukotriene biosynthesis, IEA11 genes
ligand-dependent nuclear receptor transcription coactivator activity, NAS11 genes
Lipase, Lipase10 genes
LBP_BPI_CETP_C, LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar10 genes
learning and/or memory, TAS10 genes
Lys, C-type lysozyme/alpha-lactalbumin family. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bact9 genes
Lamp, Lysosome-associated membrane glycoprotein (Lamp)9 genes
L27, L27 domain. The L27 domain is found in receptor targeting proteins Lin-2 and Lin-79 genes
Ldh_1_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydroge9 genes
lysosome, NAS9 genes
lipid binding, TAS9 genes
Laminin_B, Laminin B (Domain IV)8 genes
Ldh_1_N, lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are 8 genes
LRRNT, Leucine rich repeat N-terminal domain. Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domai8 genes
LAG1, Longevity-assurance protein (LAG1). Members of this family are involved in determining life span. The molecular mechanisms by which LAG1 determines longevity are unclear, although some evidence suggest a participation in ceramide synthes8 genes
lysosphingolipid and lysophosphatidic acid receptor activity, IEA8 genes
lipid transporter activity, NR8 genes
L-fucose catabolism, NAS8 genes
Lipoprotein_7, Adhesin lipoprotein. This family consists of the p50 and variable adherence-associated antigen (Vaa) adhesins from Mycoplasma hominis. M. hominis is a mycoplasma associated with human urogenital diseases, pneumonia, and septic a7 genes
lysozyme activity, IEA7 genes
Lipoxygenase, Lipoxygenase6 genes
Lipase_GDSL, GDSL-like Lipase/Acylhydrolase6 genes
LysM, LysM domain. The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this d6 genes
LEM, LEM domain. The LEM domain is 50 residues long and is composed of two parallel alpha helices. This domain is found in inner nuclear membrane proteins. It is called the LEM domain after LAP2, Emerin and Man16 genes
Lipase_chap, Proteobacterial lipase chaperone protein6 genes
LCCL, LCCL domain6 genes
La, La domain. This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain6 genes
L6_membrane, L6 membrane protein. This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignmen6 genes
L-serine biosynthesis, IEA6 genes
latrotoxin receptor activity, IEA6 genes
Ligase_CoA, CoA-ligase. This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP5 genes
Lysyl_oxidase, Lysyl oxidase5 genes
LON, ATP-dependent protease La (LON) domain5 genes
LMBR1, LMBR1-like membrane protein. Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play 5 genes
Laminin_II, Laminin Domain II. coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure5 genes
Lung_7-TM_R, Lung seven transmembrane receptor. This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins5 genes
long-chain-fatty-acid-CoA ligase activity, TAS5 genes
L-phenylalanine catabolism, IEA5 genes
lipid transport, TAS5 genes
leukocyte cell adhesion, NAS5 genes
lipopolysaccharide biosynthesis, IEA5 genes
lamellipodium, ISS5 genes
Lyase_1, Lyase4 genes
LUC7, LUC7 N_terminus. This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The fam4 genes
Lectin_leg-like, Legume-like lectin family. Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 and ERGIC-53 lectins. These two proteins were the first recognised members of a family of4 genes
Lectin_N, Hepatic lectin, N-terminal domain4 genes
LANC_like, Lanthionine synthetase C-like protein. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1(P40 seven-transmembrane-domain prot4 genes
LR8, LR8 protein. This family consists of several LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts4 genes
Lep_receptor_Ig, Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge4 genes
ligand-regulated transcription factor activity, TAS4 genes
L-glutamate transporter activity, TAS4 genes
laminin-1, IEA4 genes
lysosomal membrane, TAS4 genes
lipid biosynthesis, IEA4 genes
L-glutamate transport, TAS4 genes
large ribosomal subunit, IEA4 genes
lipoxygenase activity, IEA4 genes
lipoate-protein ligase B activity, IEA4 genes
Lipase_3, Lipase (class 3)3 genes
Latrophilin, Latrophilin Cytoplasmic C-terminal region. This family consists of the cytoplasmic C-terminal region in latrophilin. Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin3 genes
Lipoprotein_14, Actinobacillus constitutively-expressed outer membrane lipoprotein A3 genes
LCM, Leucine carboxyl methyltransferase. Family of leucine carboxyl methyltransferases EC:2.1.1.-. This family may need divides a the full alignment contains a significantly shorter mouse sequence3 genes
LTV, Low temperature viability protein3 genes
L51_S25_CI-B8, Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain. The proteins in this family are located in the mitochondrion. The family includes ribosomal protein L51, and S25. This family also includes mitochondrial NADH-ubiquinone 3 genes
L-lactate dehydrogenase activity, TAS3 genes
lipoprotein lipase activity, TAS3 genes
lysophospholipase activity, TAS3 genes
ligand-dependent nuclear receptor activity, IEA3 genes
lamin binding, TAS3 genes
lysosomal membrane, NR3 genes
lipid metabolism, NAS3 genes
lipid transport, NAS3 genes
locomotory behavior, TAS3 genes
lipoprotein binding, TAS3 genes
L-cystine transporter activity, TAS3 genes
lipid glycosylation, IEA3 genes
L15, Ribosomal protein L152 genes
LIF_OSM, LIF / OSM family2 genes
LIM_bind, LIM-domain binding protein. The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 2 genes
LACT, Lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase (LACT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol2 genes
Lipin_N, lipin, N-terminal conserved region. Mutations in the lipin gene lead to fatty liver dystrophy in mice. The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserve2 genes
Laminin_A, Laminin A2 genes
Lon_C, Lon protease (S16) C-terminal proteolytic domain. The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal pro2 genes
LAP1C, Lamina-associated polypeptide 1C (LAP1C). This family contains rat LAP1C proteins and several uncharacterised highly related sequences from both mice and humans. LAP1s (lamina-associated polypeptide 1s) are type 2 integral membrane prot2 genes
Latexin, Latexin. This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat2 genes
lipopolysaccharide binding, NAS2 genes
L-lactate dehydrogenase activity, IEA2 genes
long-chain-acyl-CoA dehydrogenase activity, TAS2 genes
long-chain-fatty-acid-CoA ligase activity, IEA2 genes
lysophosphatidate acyltransferase activity, TAS2 genes
lysophospholipase activity, IEA2 genes
leukotriene receptor activity, TAS2 genes
low-density lipoprotein receptor activity, TAS2 genes
lipid transporter activity, NAS2 genes
laminin-5, NR2 genes
lamin filament, TAS2 genes
lysosome, IDA2 genes
lysyl-tRNA aminoacylation, IEA2 genes
leukotriene metabolism, TAS2 genes
lysosome organization and biogenesis, IEA2 genes
leukocyte cell adhesion, IDA2 genes
leukocyte cell adhesion, TAS2 genes
lactation, TAS2 genes
learning and/or memory, ISS2 genes
learning, TAS2 genes
locomotory behavior, NAS2 genes
lipid binding, NAS2 genes
low voltage-gated calcium channel activity, TAS2 genes
ligand-gated ion channel activity, TAS2 genes
L-cystine transport, TAS2 genes
lipoxygenase activity, TAS2 genes
low-density lipoprotein binding, IDA2 genes
lung development, ISS2 genes
ligand-dependent nuclear receptor transcription coactivator activity, IPI2 genes
ligand-dependent nuclear receptor transcription coactivator activity, ISS2 genes
lymphocyte chemotaxis, IDA2 genes
leukotriene-B4 20-monooxygenase activity, IEA2 genes
LacY_symp, LacY proton/sugar symporter. This family is closely related to the sugar transporter family1 genes
LMWPc, Low molecular weight phosphotyrosine protein phosphatase1 genes
Leptin, Leptin1 genes
LEA_4, Late embryogenesis abundant protein. Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress. The function of these proteins is unkn1 genes
LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribu1 genes
Leo1, Leo1-like protein. Members of this family are part of the Paf1/RNA polymerase II complex. The Paf1 complex probably functions during the elongation phase of transcription1 genes
Las1, Las1-like. Las1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth1 genes
LicD, LICD Protein Family. The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased abili1 genes
LST1, LST-1 protein. B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expresse1 genes
LECT2, Leukocyte cell-derived chemotaxin 2 (LECT2). This family consists of several leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact f1 genes
LuxC, Acyl-CoA reductase (LuxC). This family consists of several bacterial Acyl-CoA reductase (LuxC) proteins. The channelling of fatty acids into the fatty aldehyde substrate for the bacterial bioluminescence reaction is catalysed by a fatty 1 genes
Lamprin, Lamprin. This family consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix1 genes
LepA_C, GTP-binding protein LepA C-terminus. This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins1 genes
LEAP-2, Liver-expressed antimicrobial peptide 2 precursor (LEAP-2). This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cysteine-rich, and cationic protein. LEAP-2 contains a core s1 genes
lactase activity, TAS1 genes
L-ornithine transporter activity, NAS1 genes
L-ornithine transporter activity, TAS1 genes
lanosterol synthase activity, TAS1 genes
legumain activity, IEA1 genes
legumain activity, TAS1 genes
lipid raft polarization, TAS1 genes
left-handed Z-DNA binding, NAS1 genes
lysozyme activity, NAS1 genes
L-iditol 2-dehydrogenase activity, IEA1 genes
L-iduronidase activity, TAS1 genes
L-serine ammonia-lyase activity, TAS1 genes
leucyl aminopeptidase activity, IDA1 genes
leucyl aminopeptidase activity, IEA1 genes
leucyl aminopeptidase activity, NAS1 genes
lysine carboxypeptidase activity, IEA1 genes
lysine carboxypeptidase activity, TAS1 genes
lysosomal Pro-X carboxypeptidase activity, IEA1 genes
lactose synthase activity, IEA1 genes
lactoylglutathione lyase activity, TAS1 genes
leukotriene-C4 synthase activity, TAS1 genes
lipoprotein lipase activity, IEA1 genes
lipoprotein lipase activity, NR1 genes
lysophospholipase activity, NAS1 genes
leucine-tRNA ligase activity, IEA1 genes
lysine-tRNA ligase activity, IDA1 genes
lysine-tRNA ligase activity, IEA1 genes
lysine-tRNA ligase activity, TAS1 genes
ligand-dependent nuclear receptor activity, IDA1 genes
ligand-dependent nuclear receptor activity, TAS1 genes
leukemia inhibitory factor receptor activity, TAS1 genes
lutropin-choriogonadotropic hormone receptor activity, IEA1 genes
leukotriene receptor activity, IEA1 genes
leukotriene receptor activity, NAS1 genes
low-density lipoprotein receptor activity, IDA1 genes
low-density lipoprotein receptor activity, NAS1 genes
low-density lipoprotein receptor activity, NR1 genes
laminin receptor activity, NR1 genes
laminin receptor activity, TAS1 genes
leukemia inhibitory factor receptor binding, NR1 genes
leukemia inhibitory factor receptor binding, TAS1 genes
luteinizing hormone-releasing factor activity, TAS1 genes
L-tyrosine transporter activity, TAS1 genes
L-glutamate transporter activity, IDA1 genes
low-affinity glucose:sodium symporter activity, TAS1 genes
lamin binding, IPI1 genes
laminin-1, NAS1 genes
laminin-3, NAS1 genes
laminin-5, ISS1 genes
lysosome, IEP1 genes
lysosomal membrane, NAS1 genes
late endosome, IEP1 genes
late endosome, ISS1 genes
late endosome, NAS1 genes
late endosome, TAS1 genes
lipid particle, NAS1 genes
lipid particle, NR1 genes
lipid particle, TAS1 genes
lactose biosynthesis, TAS1 genes
loss of chromatin silencing, NAS1 genes
loss of chromatin silencing, TAS1 genes
leucyl-tRNA aminoacylation, IEA1 genes
lysyl-tRNA aminoacylation, IDA1 genes
leucine catabolism, NAS1 genes
leucine catabolism, TAS1 genes
L-phenylalanine catabolism, NAS1 genes
L-phenylalanine catabolism, NR1 genes
L-phenylalanine catabolism, TAS1 genes
L-serine metabolism, IEA1 genes
L-serine metabolism, NAS1 genes
L-serine metabolism, TAS1 genes
L-serine biosynthesis, NAS1 genes
L-serine biosynthesis, NR1 genes
L-serine catabolism, NR1 genes
leukotriene metabolism, NAS1 genes
lipid transport, ISS1 genes
lysosome organization and biogenesis, IDA1 genes
lysosome organization and biogenesis, TAS1 genes
lysosomal transport, TAS1 genes
leukocyte cell adhesion, NR1 genes
lymph gland development, NAS1 genes
lymph gland development, TAS1 genes
lactation, IEA1 genes
lactation, ISS1 genes
lactation, NAS1 genes
lactation, NR1 genes
learning and/or memory, NAS1 genes
learning and/or memory, NR1 genes
long-term memory, NAS1 genes
lipoprotein binding, ISS1 genes
lipid binding, NR1 genes
low voltage-gated calcium channel activity, NAS1 genes
lipid biosynthesis, ISS1 genes
lipid biosynthesis, NAS1 genes
L-fucose isomerase activity, IEA1 genes
lipopolysaccharide biosynthesis, NAS1 genes
lipoate biosynthesis, IEA1 genes
light-harvesting complex (sensu Viridiplantae), IEA1 genes
low affinity phosphate transporter activity, TAS1 genes
lactate transporter activity, TAS1 genes
L-aspartate transporter activity, TAS1 genes
L-serine transporter activity, TAS1 genes
L-tryptophan transporter activity, TAS1 genes
ligand-gated ion channel activity, NR1 genes
low affinity sodium:dicarboxylate symporter activity, TAS1 genes
lactate transport, TAS1 genes
L-aspartate transport, TAS1 genes
L-glutamate transport, IDA1 genes
L-proline transport, TAS1 genes
large ribosomal subunit, TAS1 genes
lipid catabolism, ISS1 genes
lipid catabolism, NAS1 genes
lateral plasma membrane, IDA1 genes
lambda DNA polymerase activity, NAS1 genes
latrotoxin receptor activity, NAS1 genes
lyase activity, NAS1 genes
ligand-dependent nuclear receptor interactor activity, IDA1 genes
lipoate synthase activity, IEA1 genes
leukotriene biosynthesis, IDA1 genes
L-ascorbic acid metabolism, NAS1 genes
lamellipodium, IDA1 genes
lamellipodium, NAS1 genes
L-malate dehydrogenase activity, IEA1 genes
L-malate dehydrogenase activity, NAS1 genes
lipid glycosylation, NAS1 genes
LIM domain binding, IPI1 genes
LRR domain binding, NAS1 genes
ligand-dependent nuclear receptor transcription coactivator activity, IDA1 genes
ligand-dependent nuclear receptor transcription coactivator activity, IMP1 genes
long-term strengthening of neuromuscular junction, IDA1 genes
lipoprotein metabolism, NAS1 genes
lipid raft, IDA1 genes
low-density lipoprotein catabolism, NAS1 genes
low-density lipoprotein catabolism, TAS1 genes
leptomycin B-sensitive MAPK phosphatase nucleus export, TAS1 genes
L-methylmalonyl-CoA metabolism, NAS1 genes
lipopolysaccharide receptor complex, NAS1 genes
lactosylceramide alpha-2,3-sialyltransferase activity, IDA1 genes
lymphocyte chemotaxis, ISS1 genes
L-pipecolate oxidase activity, IEA1 genes
lathosterol oxidase activity, IEA1 genes
lactosylceramide 4-alpha-galactosyltransferase activity, IEA1 genes
low-density lipoprotein receptor binding, NAS1 genes
leukocyte adhesive activation, TAS1 genes
AS3D: Alternative Splicing Structural Genomics Projects
CARB/UMBI