| hydrolase activity, IEA | 831 genes |
| Homeobox, Homeobox domain | 231 genes |
| HOOK, HOOK protein. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three hum | 229 genes |
| Herpes_BLLF1, Herpes virus major outer envelope glycoprotein (BLLF1). This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses | 211 genes |
| Herpes_gp2, Equine herpesvirus glycoprotein gp2. This family consists of a number of glycoprotein gp2 sequences from equine herpesviruses | 151 genes |
| Herpes_LMP2, Gammaherpesvirus latent membrane protein (LMP2) protein. This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus is a human Gammaherpesvirus that infects and establishes latency | 111 genes |
| Helicase_C, Helicase conserved C-terminal domain. TThis domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase | 103 genes |
| homophilic cell adhesion, IEA | 100 genes |
| HLH, Helix-loop-helix DNA-binding domain | 96 genes |
| heterophilic cell adhesion, IEA | 86 genes |
| Histone, Core histone H2A/H2B/H3/H4 | 82 genes |
| Herpes_UL32, Herpesvirus large structural phosphoprotein UL32. The large phosphorylated protein (UL32-like) of herpes viruses is the polypeptide most frequently reactive in immuno-blotting analyses with antisera when compared with other viral | 73 genes |
| HMG_box, HMG (high mobility group) box | 64 genes |
| HCR, Alpha helical coiled-coil rod protein (HCR). This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect k | 60 genes |
| Hormone_recep, Ligand-binding domain of nuclear hormone receptor. This all helical domain is involved in binding the hormone in these receptors | 48 genes |
| Herpes_TAF50, Herpesvirus transcription activation factor (transactivator). This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses | 43 genes |
| HSP90, Hsp90 protein | 39 genes |
| hydrolase activity, acting on glycosyl bonds, IEA | 39 genes |
| Hydrolase, haloacid dehalogenase-like hydrolase. This family are structurally different from the alpha/ beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of th | 37 genes |
| hormone activity, IEA | 37 genes |
| heparin binding, IEA | 36 genes |
| hydrogen-transporting ATP synthase activity, rotational mechanism, IEA | 33 genes |
| HAP1_N, HAP1 N-terminal conserved region. This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. How | 32 genes |
| HSP70, Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus | 30 genes |
| hydrogen-transporting ATPase activity, rotational mechanism, IEA | 30 genes |
| hematopoietin/interferon-class (D200-domain) cytokine receptor activity, IEA | 28 genes |
| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, IEA | 28 genes |
| hormone activity, TAS | 27 genes |
| HECT, HECT-domain (ubiquitin-transferase). The name HECT comes from Homologous to the E6-AP Carboxyl Terminus | 24 genes |
| HRM, Hormone receptor domain. This extracellular domain contains four conserved cysteines that probably for disulphide bridges. The domain is found in a variety of hormone receptors. It may be a ligand binding domain | 24 genes |
| humoral immune response, TAS | 24 genes |
| helicase activity, IEA | 22 genes |
| heterotrimeric G-protein complex, IEA | 22 genes |
| HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90 | 20 genes |
| HA2, Helicase associated domain (HA2). This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding | 20 genes |
| heme binding, IEA | 20 genes |
| hydrolase activity, hydrolyzing O-glycosyl compounds, IEA | 19 genes |
| Hemopexin, Hemopexin. Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibit | 18 genes |
| Harpin, Harpin protein (HrpN). This family consists of several bacterial HrpN harpin proteins. HrpN is a virulence determinant which elicits lesion formation in Arabidopsis and tobacco and triggers systemic resistance in Arabidopsis | 17 genes |
| heat shock protein activity, TAS | 17 genes |
| HABP4_PAI-RBP1, Hyaluronan / mRNA binding family. This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is n | 15 genes |
| Halo_GVPC, Halobacterial gas vesicle protein C (GVPC). This family consists of Halobacterium gas vesicle protein C sequences which are thought to confer stability to the gas vesicle membranes | 14 genes |
| heart development, TAS | 14 genes |
| Herpes_UL51, Herpesvirus UL51 protein. UL51 protein is a virion protein. In pseudorabies virus, UL51 was identified as a component of the capsid. In herpes simplex virus type 1 there is evidence for post-translational modification of UL51 | 13 genes |
| hemopoiesis, NAS | 13 genes |
| HlyD, HlyD family secretion protein | 12 genes |
| heterogeneous nuclear ribonucleoprotein complex, TAS | 12 genes |
| HSP20, Hsp20/alpha crystallin family | 11 genes |
| Hist_deacetyl, Histone deacetylase family. Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyse the removal of the acetyl group. Histon | 11 genes |
| histone deacetylase complex, TAS | 11 genes |
| heat shock protein activity, IEA | 11 genes |
| heparin binding, TAS | 11 genes |
| hydrolase activity, acting on ester bonds, IEA | 11 genes |
| HCO3_cotransp, HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3- | 10 genes |
| Herpes_glycop_D, Herpesvirus glycoprotein D. Herpesviruses are dsDNA viruses with no RNA stage. This is a family consists of glycoprotein-D (gD or gIV) which is common to herpes simplex virus types 1 and 2, as well as equine herpes, bovine her | 10 genes |
| Herpes_DNAp_acc, Herpes DNA replication accessory factor. Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dep | 10 genes |
| HGTP_anticodon, Anticodon binding domain. This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases; it is probably the anticodon binding domain | 9 genes |
| hyaluronic acid binding, IEA | 9 genes |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, IEA | 9 genes |
| HSF_DNA-bind, HSF-type DNA-binding | 8 genes |
| heme biosynthesis, TAS | 8 genes |
| homophilic cell adhesion, NAS | 8 genes |
| hemocyte development, TAS | 8 genes |
| hydrogen ion transporter activity, IEA | 8 genes |
| HIT, HIT domain | 7 genes |
| HR1, Hr1 repeat | 7 genes |
| HemX, HemX. This family consists of several bacterial HemX proteins. The hemX gene is not essential for haem synthesis in B. subtilis. HemX is a polytopic membrane protein which by an unknown mechanism down-regulates the level of HemA | 7 genes |
| Herpes_LMP1, Herpesvirus latent membrane protein 1 (LMP1). This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning r | 7 genes |
| hormone activity, NAS | 7 genes |
| hormone activity, NR | 7 genes |
| hemoglobin complex, TAS | 7 genes |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, IEA | 7 genes |
| histone-lysine N-methyltransferase activity, IEA | 7 genes |
| Hormone_1, Somatotropin hormone family | 6 genes |
| Hormone_2, Peptide hormone. This family contains glucagon, GIP, secretin and VIP | 6 genes |
| HELP, HELP motif. The HELP (Hydrophobic ELP) motif is found in EMAP and EMAP-like proteins (ELPs). The HELP motif contains a predicted transmembrane helix so probably does not form a globular domain. It is also not clear if these proteins loca | 6 genes |
| HIG_1_N, Hypoxia induced protein conserved region. This family is found in proteins thought to be involved in the response to hypoxia. Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identifie | 6 genes |
| heterotrimeric G-protein complex, TAS | 6 genes |
| homophilic cell adhesion, TAS | 6 genes |
| Hexokinase_1, Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains | 5 genes |
| HesB, HesB-like domain. This family includes HesB which may be involved in nitrogen fixation; the hesB gene is expressed only under nitrogen fixation conditions. Other members of this family include various hypothetical proteins of which some | 5 genes |
| Herpes_gI, Alphaherpesvirus glycoprotein I. This family consists of glycoprotein I form various members of the alphaherpesvirinae these include herpesvirus, varicella-zoster virus and pseudorabies virus. Glycoprotein I (gI) is important during | 5 genes |
| Herpes_gG, Glycoprotein GG/GX. Glycoprotein G (gG)is one of the seven external glycoproteins of HSV1 and HSV2. This family also contains the glycoprotein GX, (gX), initially identified in Pseudorabies virus | 5 genes |
| Hexokinase_2, Hexokinase. Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains | 5 genes |
| hATC, hAT family dimerisation domain. This dimerisation domain is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerisation domain forms extremely stable | 5 genes |
| histone deacetylase activity, TAS | 5 genes |
| heterotrimeric G-protein complex, NAS | 5 genes |
| heme biosynthesis, IEA | 5 genes |
| hemostasis, TAS | 5 genes |
| heparin binding, NAS | 5 genes |
| HMA, Heavy-metal-associated domain | 4 genes |
| HRDC, HRDC domain. The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease | 4 genes |
| HhH-GPD, HhH-GPD superfamily base excision DNA repair protein. This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro ri | 4 genes |
| HORMA, HORMA domain. The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other | 4 genes |
| HIN, HIN-200/IF120x domain. This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain pfam02758 | 4 genes |
| Hamartin, Hamartin protein. This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal domi | 4 genes |
| Hox9_act, Hox9 activation region. This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is thought to act as a transcription activation region. Activation is may be by in | 4 genes |
| HS6ST, Heparan sulfate 6-sulfotransferase (HS6ST). This family consists of several heparan sulfate 6-sulfotransferase (HS6ST) proteins. Heparan sulphate 6- O -sulphotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosp | 4 genes |
| heat shock protein activity, NAS | 4 genes |
| histone acetyltransferase activity, IEA | 4 genes |
| hyalurononglucosaminidase activity, TAS | 4 genes |
| histamine receptor activity, TAS | 4 genes |
| hematopoietin/interferon-class (D200-domain) cytokine receptor binding, TAS | 4 genes |
| heart development, ISS | 4 genes |
| hedgehog receptor activity, IEA | 4 genes |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, IEA | 4 genes |
| hydrogen-transporting ATPase activity, rotational mechanism, TAS | 4 genes |
| Hormone_3, Pancreatic hormone peptide | 3 genes |
| HMGL-like, HMGL-like. This family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase | 3 genes |
| Hint, Hint module. This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module | 3 genes |
| HH_signal, Hedgehog amino-terminal signaling domain. For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation | 3 genes |
| HNF-1_N, Hepatocyte nuclear factor 1 (HNF-1), N terminus. This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence, and an acidic region that may be involved in tran | 3 genes |
| Herpes_U47, Herpesvirus glycoprotein U47 | 3 genes |
| H2TH, Formamidopyrimidine-DNA glycosylase H2TH domain. Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn | 3 genes |
| HCaRG, HCaRG protein. This family consists of several mammalian HCaRG(hypertension-related, calcium-regulated gene) proteins. HCaRG is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hyperte | 3 genes |
| histone deacetylase complex, IDA | 3 genes |
| heparin N-deacetylase/N-sulfotransferase activity, TAS | 3 genes |
| hexokinase activity, IEA | 3 genes |
| hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, TAS | 3 genes |
| hyaluronic acid binding, TAS | 3 genes |
| hemoglobin complex, NAS | 3 genes |
| homophilic cell adhesion, NR | 3 genes |
| heparin binding, NR | 3 genes |
| hydrogen-exporting ATPase activity, phosphorylative mechanism, IEA | 3 genes |
| hormone mediated signaling, IEA | 3 genes |
| histone deacetylation, IDA | 3 genes |
| histone deacetylation, IEA | 3 genes |
| hemopoiesis, TAS | 3 genes |
| heparan sulfate proteoglycan metabolism, NAS | 3 genes |
| hydrogen ion homeostasis, ISS | 3 genes |
| hindbrain development, ISS | 3 genes |
| hyaluronan synthase activity, IEA | 3 genes |
| Hormone_5, Neurohypophysial hormones, C-terminal Domain. N-terminal Domain is in hormone5 | 2 genes |
| HHH, Helix-hairpin-helix motif. The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA | 2 genes |
| HMG14_17, HMG14 and HMG17 | 2 genes |
| Heme_oxygenase, Heme oxygenase | 2 genes |
| HMG_CoA_synt, Hydroxymethylglutaryl-coenzyme A synthase | 2 genes |
| Hydantoinase_A, Hydantoinase/oxoprolinase. This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds | 2 genes |
| HS1_rep, Repeat in HS1/Cortactin. The function of this repeat is unknown. Seven copies are found in cortactin and four copies are found in HS1. The repeats are always found amino terminal to an SH3 domain pfam00018 | 2 genes |
| Herpes_gE, Alphaherpesvirus glycoprotein E. Glycoprotein E (gE) of Alphaherpesvirus forms a complex with glycoprotein I (gI) (pfam01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not es | 2 genes |
| HYR, HYR domain. This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of th | 2 genes |
| HEAT, HEAT repeat. The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). CAUTION: This family does not contain all known HEAT repeats | 2 genes |
| HHV6-IE, Human herpesvirus 6 immediate early protein. The proteins in this family are poorly characterized, but an investigationhas indicated that the immediate early protein is required the down-regulation of MHC class I expression in dendrit | 2 genes |
| Hrf1, Hrf1 family. This family includes a number of eukaryotic proteins. It is an integral membrane protein, conserved in at least 1 copy in all sequenced eukaryotes. The gene name in S. pombe is hrf1+ for Heavy metal Resistance Factor 1 (unpu | 2 genes |
| Hus1, Hus1-like protein. Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo. Hus1-Rad1-Rad9 complex may form a PCNA-like | 2 genes |
| HNF-1B_C, Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus. This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Differe | 2 genes |
| HS2ST, Heparan sulfate 2-O-sulfotransferase (HS2ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand int | 2 genes |
| HrpE, HrpE protein. This family consists of several bacterial HrpE proteins. The exact function of this family is unknown but it is thought that HrpE is involved in the secretion of HrpZ (harpinPss) | 2 genes |
| Hyd_WA, Propeller. Probable beta-propeller | 2 genes |
| HSBP1, Heat shock factor binding protein 1. Heat shock factor binding protein 1 (HSBP1) appears to be a negative regulator of the heat shock response | 2 genes |
| histone-specific chaperone activity, TAS | 2 genes |
| heat shock protein activity, ISS | 2 genes |
| helicase activity, TAS | 2 genes |
| heme oxygenase (decyclizing) activity, TAS | 2 genes |
| hexokinase activity, TAS | 2 genes |
| histone acetyltransferase activity, TAS | 2 genes |
| H3/H4 histone acetyltransferase activity, TAS | 2 genes |
| histone deacetylase activity, IDA | 2 genes |
| histone deacetylase activity, NAS | 2 genes |
| hyalurononglucosaminidase activity, IEA | 2 genes |
| hydroxymethylglutaryl-CoA synthase activity, IEA | 2 genes |
| histidine-tRNA ligase activity, NAS | 2 genes |
| hematopoietin/interferon-class (D200-domain) cytokine receptor binding, IEA | 2 genes |
| hemoglobin complex, IEA | 2 genes |
| histidyl-tRNA aminoacylation, IEA | 2 genes |
| histidine catabolism, IEA | 2 genes |
| heme oxidation, IEA | 2 genes |
| humoral immune response, NR | 2 genes |
| hyperosmotic response, NAS | 2 genes |
| heterophilic cell adhesion, TAS | 2 genes |
| high-density lipoprotein binding, NR | 2 genes |
| high-density lipoprotein binding, TAS | 2 genes |
| Hsp70/Hsp90 organizing protein activity, TAS | 2 genes |
| heparin binding, IDA | 2 genes |
| heparin-glucosamine 3-O-sulfotransferase activity, IEA | 2 genes |
| homocysteine S-methyltransferase activity, IEA | 2 genes |
| hydrogen:potassium-exchanging ATPase activity, TAS | 2 genes |
| heparan sulfate proteoglycan biosynthesis, enzymatic modification, TAS | 2 genes |
| heme transporter activity, TAS | 2 genes |
| humoral defense mechanism (sensu Vertebrata), NAS | 2 genes |
| hydrolase activity, TAS | 2 genes |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, IEA | 2 genes |
| heme binding, ISS | 2 genes |
| hemoglobin binding, IEA | 2 genes |
| histone acetyltransferase binding, ISS | 2 genes |
| histone binding, IDA | 2 genes |
| hormone biosynthesis, ISS | 2 genes |
| hemoglobin biosynthesis, IDA | 2 genes |
| homeostasis, NAS | 2 genes |
| hydroxyapatite binding, NAS | 2 genes |
| histone lysine N-methyltransferase activity (H3-K9 specific), IDA | 2 genes |
| Hormone_6, Glycoprotein hormone | 1 genes |
| HMG-CoA_red, Hydroxymethylglutaryl-coenzyme A reductase | 1 genes |
| Hemagglutinin, Hemagglutinin. Hemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalises the virus by endocytosis. The drop of pH causes release of a h | 1 genes |
| His_biosynth, Histidine biosynthesis protein. Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalysed by eight e | 1 genes |
| HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI | 1 genes |
| Ham1p_like, Ham1 family. This family consists of the HAM1 protein, and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae. The HAM1 protein protects | 1 genes |
| Herpes_UL6, Herpesvirus UL6 like. This family consists of various proteins from the herpesviridae that are similar to herpes simplex virus type I UL6 virion protein. UL6 is essential for cleavage and packaging of the viral genome | 1 genes |
| HNH, HNH endonuclease | 1 genes |
| HD, HD domain. HD domains are metal dependent phosphohydrolases | 1 genes |
| HAT, HAT (Half-A-TPR) repeat. The HAT (Half A TPR) repeat is found in several RNA processing proteins | 1 genes |
| Hex_IIIa, Hexon-associated protein (IIIa). The major capsid protein of the adenovirus strain is also known as a hexon. This is a family of hexon-associated proteins (protein IIIa) | 1 genes |
| Hydantoinase_B, Hydantoinase B/oxoprolinase. This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase EC:3.5.2.9 which catalyses the formation of L-glutamate from 5-oxo-L-proline. Thes | 1 genes |
| HEM4, Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyses the reaction | 1 genes |
| Hpr_kinase, HPr Serine kinase. This family consists of Hpr Serine/threonine kinase PtsK. This kinase is the sensor in a multicomponent phosphorelay system in control of carbon catabolic repression in bacteria. This kinase in unusual in that it | 1 genes |
| H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating | 1 genes |
| HpaB, 4-hydroxyphenylacetate 3-hydroxylase family. HpaB encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli. HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD a | 1 genes |
| Huntingtin, Huntingtin | 1 genes |
| HgmA, homogentisate 1,2-dioxygenase. Homogentisate dioxygenase cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria. The structure of homogentisate dioxygenase show | 1 genes |
| HNF-1A_C, Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus. This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generate | 1 genes |
| HTH_psq, helix-turn-helix, Psq domain. This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence | 1 genes |
| Hydant_A_N, Hydantoinase/oxoprolinase N-terminal region. This family is found at the N-terminus of the pfam01968 family | 1 genes |
| Herpes_capsid, Gammaherpesvirus capsid protein. This family consists of several Gammaherpesvirus capsid proteins. The exact function of this family is unknown | 1 genes |
| HSL_N, Hormone-sensitive lipase (HSL) N-terminus. This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, an | 1 genes |
| Hepcidin, Hepcidin. Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphid | 1 genes |
| HemN_C, HemN C-terminal region. Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX, one of the la | 1 genes |
| Hep_59, Hepatocellular carcinoma-associated antigen 59. This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 and similar proteins. Family members are found in | 1 genes |
| Herpes_IE1, Cytomegalovirus IE1 protein. Expression from a human cytomegalovirus early promoter (E1.7) has been shown to be activated in trans by the IE2 gene product. Although the IE1 gene product alone had no effect on this early viral promo | 1 genes |
| HC2, Histone H1-like nucleoprotein HC2. This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has bee | 1 genes |
| HARP, HepA-related protein (HARP). This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously express | 1 genes |
| HyaE, Hydrogenase-1 expression protein HyaE. This family contains bacterial hydrogenase-1 expression proteins approximately 120 residues long. This includes the E. coli protein HyaE, and the homologous proteins HoxO of R. eutropha and HupG of | 1 genes |
| histidine biosynthesis, IEA | 1 genes |
| histamine biosynthesis, IDA | 1 genes |
| heat shock protein activity, NR | 1 genes |
| helicase activity, NAS | 1 genes |
| hexaprenyldihydroxybenzoate methyltransferase activity, IEA | 1 genes |
| hexokinase activity, NAS | 1 genes |
| histidine ammonia-lyase activity, IEA | 1 genes |
| histidine decarboxylase activity, TAS | 1 genes |
| histone acetyltransferase activity, IEP | 1 genes |
| histone acetyltransferase activity, ISS | 1 genes |
| holocytochrome-c synthase activity, TAS | 1 genes |
| homoaconitate hydratase activity, ISS | 1 genes |
| homogentisate 1,2-dioxygenase activity, IEA | 1 genes |
| hyalurononglucosaminidase activity, NR | 1 genes |
| hydroxyacylglutathione hydrolase activity, TAS | 1 genes |
| hydroxymethylbilane synthase activity, TAS | 1 genes |
| hydroxymethylglutaryl-CoA lyase activity, IEA | 1 genes |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity, IEA | 1 genes |
| hydroxymethylglutaryl-CoA synthase activity, TAS | 1 genes |
| hypoxanthine phosphoribosyltransferase activity, IEA | 1 genes |
| hypoxanthine phosphoribosyltransferase activity, TAS | 1 genes |
| hematopoietin/interferon-class (D200-domain) cytokine receptor activity, TAS | 1 genes |
| histamine receptor activity, IEA | 1 genes |
| histamine receptor activity, NAS | 1 genes |
| hepatocyte growth factor receptor activity, TAS | 1 genes |
| hematopoietin/interferon-class (D200-domain) cytokine receptor binding, NAS | 1 genes |
| hyaluronic acid binding, NAS | 1 genes |
| hyaluronic acid binding, NR | 1 genes |
| heterotrimeric G-protein complex, NR | 1 genes |
| hydrogen:potassium-exchanging ATPase complex, TAS | 1 genes |
| histone mRNA 3'-end processing, NAS | 1 genes |
| histone mRNA 3'-end processing, TAS | 1 genes |
| histidine metabolism, IEA | 1 genes |
| histidine metabolism, TAS | 1 genes |
| humoral immune response, IEA | 1 genes |
| heterophilic cell adhesion, ISS | 1 genes |
| heart development, IMP | 1 genes |
| heart development, NAS | 1 genes |
| hemostasis, NAS | 1 genes |
| high-density lipoprotein binding, NAS | 1 genes |
| Hsp70/Hsp90 organizing protein activity, NAS | 1 genes |
| heparin binding, ISS | 1 genes |
| histone mRNA metabolism, TAS | 1 genes |
| heparin-glucosamine 3-O-sulfotransferase activity, IDA | 1 genes |
| heparin-glucosamine 3-O-sulfotransferase activity, NAS | 1 genes |
| heparin-glucosamine 3-O-sulfotransferase activity, TAS | 1 genes |
| hypusine biosynthesis from peptidyl-lysine, IEA | 1 genes |
| holo-[acyl-carrier protein] synthase activity, IEA | 1 genes |
| homocysteine S-methyltransferase activity, TAS | 1 genes |
| hydrogen:potassium-exchanging ATPase activity, IEA | 1 genes |
| hypersensitive response, TAS | 1 genes |
| hormone mediated signaling, IDA | 1 genes |
| hormone mediated signaling, ISS | 1 genes |
| hormone transport, NAS | 1 genes |
| heparan sulfate proteoglycan biosynthesis, ISS | 1 genes |
| heparan sulfate proteoglycan biosynthesis, TAS | 1 genes |
| heparan sulfate proteoglycan biosynthesis, enzymatic modification, IDA | 1 genes |
| hydrogen ion transporter activity, ISS | 1 genes |
| hydrogen ion transporter activity, NAS | 1 genes |
| hydrogen ion channel activity, IDA | 1 genes |
| heme transport, TAS | 1 genes |
| hydrogen-translocating V-type ATPase complex, NAS | 1 genes |
| histone methylation, IDA | 1 genes |
| histone phosphorylation, IDA | 1 genes |
| histone acetylation, IDA | 1 genes |
| histone acetylation, ISS | 1 genes |
| histone acetylation, NAS | 1 genes |
| histone deacetylation, IPI | 1 genes |
| histone deacetylation, ISS | 1 genes |
| histone deacetylation, NAS | 1 genes |
| hydroxymethyl-, formyl- and related transferase activity, IEA | 1 genes |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, IEA | 1 genes |
| hydro-lyase activity, IEA | 1 genes |
| histone-lysine N-methyltransferase activity, IDA | 1 genes |
| histone-lysine N-methyltransferase activity, NAS | 1 genes |
| hexose biosynthesis, IDA | 1 genes |
| hexose biosynthesis, ISS | 1 genes |
| histidine catabolism to glutamate and formamide, IEA | 1 genes |
| hemolysis, NR | 1 genes |
| hemolysis, TAS | 1 genes |
| hemoglobin metabolism, NAS | 1 genes |
| heme binding, IPI | 1 genes |
| heme binding, NAS | 1 genes |
| hemidesmosome, IDA | 1 genes |
| hemidesmosome, ISS | 1 genes |
| hemidesmosome, TAS | 1 genes |
| hemopoiesis, ISS | 1 genes |
| HLA-B specific inhibitory MHC class I receptor activity, ISS | 1 genes |
| HLA-B specific inhibitory MHC class I receptor activity, NAS | 1 genes |
| HLA-C specific inhibitory MHC class I receptor activity, NAS | 1 genes |
| Hsp70/Hsc70 protein regulator activity, NAS | 1 genes |
| Hsp70/Hsc70 protein regulator activity, TAS | 1 genes |
| heparin biosynthesis, ISS | 1 genes |
| hyaluronan metabolism, NAS | 1 genes |
| heparanase activity, TAS | 1 genes |
| high molecular weight B-cell growth factor receptor binding, NAS | 1 genes |
| host-pathogen interaction, NAS | 1 genes |
| hemoglobin binding, NAS | 1 genes |
| heterogeneous nuclear ribonucleoprotein complex, NAS | 1 genes |
| heterogeneous nuclear ribonucleoprotein complex, NR | 1 genes |
| hydrogen ion homeostasis, IDA | 1 genes |
| heme catabolism, NAS | 1 genes |
| homoiothermy, IEA | 1 genes |
| histone binding, NAS | 1 genes |
| histone binding, TAS | 1 genes |
| hormone metabolism, NAS | 1 genes |
| hormone biosynthesis, IEP | 1 genes |
| hormone binding, IDA | 1 genes |
| hormone binding, IPI | 1 genes |
| hormone binding, ISS | 1 genes |
| histone deacetylase binding, IDA | 1 genes |
| histamine N-methyltransferase activity, IEA | 1 genes |
| host cell surface receptor binding, TAS | 1 genes |
| hydrogen-transporting ATP synthase activity, rotational mechanism, TAS | 1 genes |
| hydrogen-transporting ATPase activity, rotational mechanism, NR | 1 genes |
| hyperphosphorylation, ISS | 1 genes |
| hydrogen peroxide biosynthesis, ISS | 1 genes |
| hydrogen peroxide biosynthesis, NAS | 1 genes |
AS3D Human
