AS3D Human


We have recently updated our webserver and apologize for any inconvenience this might cause.

Quick Find
Search

Suggestions:

Gene Lists
· AS3D Targets
· Alternative Splcing
· A · B · C · D · E · F · G · H · I · J · K · L · M · N · O · P · Q · R · S · T · U · V · W · X · Y · Z All

Human Gene Lists A
ATP binding, IEA953 genes
Atrophin-1, Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPL262 genes
Ank, Ankyrin repeat. There's no clear separation between noise and signal on the HMM search Ankyrin repeats generally consist of a beta, alpha, alpha, beta order of secondary structures. The repeats associate to form a higher order structure201 genes
Arf, ADP-ribosylation factor family161 genes
apoptosis, IEA132 genes
actin binding, IEA129 genes
AF-4, AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and men72 genes
ATP-dependent helicase activity, IEA72 genes
APG6, Autophagy protein Apg6. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic pro71 genes
adh_short, short chain dehydrogenase. This family contains a wide variety of dehydrogenases65 genes
ATP binding, NAS65 genes
acyltransferase activity, IEA65 genes
antimicrobial humoral response (sensu Vertebrata), TAS61 genes
ABC_tran, ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced ba60 genes
AAA, ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes57 genes
apoptosis, TAS57 genes
anti-apoptosis, TAS51 genes
Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes46 genes
actin cytoskeleton, TAS44 genes
ANF_receptor, Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure43 genes
ATP-binding cassette (ABC) transporter activity, IEA41 genes
amino acid transport, IEA40 genes
Actin, Actin37 genes
ATP synthesis coupled proton transport, IEA36 genes
AMP-binding, AMP-binding enzyme34 genes
ATP binding, TAS34 genes
amino acid-polyamine transporter activity, IEA33 genes
ArfGap, Putative GTPase activating protein for Arf. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs32 genes
ABC_membrane, ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions27 genes
ADH_zinc_N, Zinc-binding dehydrogenase25 genes
AA_permease, Amino acid permease25 genes
ADAM_spacer1, ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases25 genes
actin binding, TAS25 genes
Adaptin_N, Adaptin N terminal region. This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formatio24 genes
Androgen_recep, Androgen receptor23 genes
angiogenesis, IEA23 genes
Arm, Armadillo/beta-catenin-like repeat. Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadil22 genes
ATP binding, IDA22 genes
Aa_trans, Transmembrane amino acid transporter protein. This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted 21 genes
amino acid metabolism, TAS21 genes
Apolipoprotein, Apolipoprotein A1/A4/E family. These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E20 genes
amino acid metabolism, IEA20 genes
antimicrobial humoral response (sensu Vertebrata), NR20 genes
actin cytoskeleton organization and biogenesis, TAS20 genes
Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Su19 genes
Aldo_ket_red, Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity19 genes
Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions19 genes
actin binding, NAS19 genes
Adap_comp_sub, Adaptor complexes medium subunit family. This family also contains members which are coatomer subunits18 genes
ATP-binding cassette (ABC) transporter activity, TAS18 genes
aromatic compound metabolism, IEA18 genes
antiporter activity, IEA18 genes
API5, Apoptosis inhibitory protein 5 (API5). This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic deve17 genes
Aminotran_1_2, Aminotransferase class I and II16 genes
adenylate cyclase activation, TAS16 genes
ADK, Adenylate kinase15 genes
ARID, ARID/BRIGHT DNA binding domain. This domain is know as ARID for AT-Rich Interaction Domain, and also known as the BRIGHT domain15 genes
Acyltransferase, Acyltransferase. This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene15 genes
activation of MAPK, TAS15 genes
alcohol dehydrogenase activity, zinc-dependent, IEA15 genes
ATP binding, ISS15 genes
Acyl-CoA_dh, Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle14 genes
actin cytoskeleton, NR14 genes
ATPase activity, IEA14 genes
Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin bindin13 genes
Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain. Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold13 genes
actin cytoskeleton, IEA13 genes
antigen presentation, exogenous antigen, IEA13 genes
antigen processing, exogenous antigen via MHC class II, IEA13 genes
Annexin, Annexin. This family of annexins also includes giardin that has been shown to function as an annexin12 genes
A2M, Alpha-2-macroglobulin family. This family includes the C-terminal region of the alpha-2-macroglobulin family12 genes
Aminotran_5, Aminotransferase class-V12 genes
ATP-dependent RNA helicase activity, TAS12 genes
anion transport, IEA12 genes
apoptosis, NAS12 genes
acute-phase response, IEA12 genes
Activin_recp, Activin types I and II receptor domain. This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino11 genes
A2M_N, Alpha-2-macroglobulin family N-terminal region. This family includes the N-terminal region of the alpha-2-macroglobulin family11 genes
axon guidance, TAS11 genes
Arrestin_N, Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain10 genes
Amidohydro_1, Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reac10 genes
Arrestin_C, Arrestin (or S-antigen), C-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain10 genes
Alpha_adaptinC2, Adaptin C-terminal domain. Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site.10 genes
Amelogenin, Amelogenin. Amelogenins play a role in biomineralisation. They seem to regulate the formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and m10 genes
An_peroxidase, Animal haem peroxidase10 genes
ATP-dependent DNA helicase activity, TAS10 genes
aminopeptidase activity, IEA10 genes
anti-apoptosis, NAS10 genes
acetylcholine receptor activity, TAS10 genes
actin cytoskeleton organization and biogenesis, NAS10 genes
androgen receptor signaling pathway, IDA10 genes
ATP-synt_B, ATP synthase B/B' CF(0). Part of the CF(0) (base unit) of the ATP synthase. The base unit is thought to translocate protons through membrane (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bac9 genes
ASC, Amiloride-sensitive sodium channel9 genes
Astacin, Astacin (Peptidase family M12A). The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. M9 genes
Acyl-CoA_dh_N, Acyl-CoA dehydrogenase, N-terminal domain. The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain9 genes
AIG1, AIG1 family. Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria9 genes
AKAP95, A-kinase anchoring protein 95 (AKAP95). A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers whic9 genes
APOBEC_C, APOBEC-like C-terminal domain. This domain is found at the C-termini of the Apolipoprotein B mRNA editing enzyme9 genes
apoptotic program, TAS9 genes
Asp, Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases 8 genes
Acid_phosphat_A, Histidine acid phosphatase8 genes
Astro_capsid, Astrovirus capsid protein precursor. This product is encoded by astrovirus ORF2, one of the three astrovirus ORFs (1a, 1b, 2). The 87kD precursor protein undergoes an intracellular cleavage to form a 79kD protein. Subsequently, e8 genes
actin binding, ISS8 genes
apoptosis, NR8 genes
aerobic respiration, TAS8 genes
antigen processing, endogenous antigen via MHC class I, IEA8 genes
Aminotran_3, Aminotransferase class-III7 genes
ACBP, Acyl CoA binding protein7 genes
Ammonium_transp, Ammonium Transporter Family7 genes
APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include:- aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kana7 genes
A1pp, Appr-1"-p processing enzyme family. This domain is found in a number of otherwise unrelated proteins. This domain is found at the C-terminus of the macro-H2A histone protein. This domain is found in the non-structural proteins of several7 genes
ATP1G1_PLM_MAT8, ATP1G1/PLM/MAT8 family7 genes
Abhydrolase_2, Phospholipase/Carboxylesterase. This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam005617 genes
ApoL, Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and 7 genes
actin binding, NR7 genes
acid phosphatase activity, IEA7 genes
ATP-dependent peptidase activity, IEA7 genes
actin filament, IEA7 genes
aldehyde metabolism, TAS7 genes
anti-apoptosis, IDA7 genes
axonogenesis, TAS7 genes
aromatic amino acid family metabolism, IEA7 genes
antigen presentation, endogenous antigen, IEA7 genes
Alpha-amylase, Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain 6 genes
ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain6 genes
AhpC-TSA, AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA)6 genes
A_deaminase, Adenosine/AMP deaminase6 genes
Anti_proliferat, BTG1 family. A novel family of anti-proliferative proteins6 genes
A_deamin, Adenosine-deaminase (editase) domain6 genes
AIRS_C, AIR synthase related protein, C-terminal domain. This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-termina6 genes
Alpha_kinase, Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-6 genes
APC10, Anaphase-promoting complex, subunit 10 (APC10)6 genes
Abhydro_lipase, ab-hydrolase associated lipase region6 genes
Arfaptin, Arfaptin-like domain. Arfaptin interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms 6 genes
acyl-CoA binding, IEA6 genes
antigen binding, TAS6 genes
ATP-binding cassette (ABC) transporter activity, NAS6 genes
aldo-keto reductase activity, TAS6 genes
adrenoceptor activity, IEA6 genes
activation of JUNK, TAS6 genes
acyltransferase activity, TAS6 genes
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, IEA6 genes
actin cytoskeleton organization and biogenesis, IEA6 genes
actin filament-based movement, NAS6 genes
ATPase activity, coupled, NR6 genes
ATPase activity, coupled, TAS6 genes
alpha(1,3)-fucosyltransferase activity, TAS6 genes
ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain. This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella5 genes
ATP-synt_C, ATP synthase subunit C5 genes
AlaDh_PNT_C, Alanine dehydrogenase/PNT, C-terminal domain. This family now also contains the lysine 2-oxoglutarate reductases5 genes
ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain. This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella5 genes
ABC1, ABC1 family. This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 5 genes
AstE_AspA, Succinylglutamate desuccinylase / Aspartoacylase family. This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The 5 genes
ARS2, Arsenite-resistance protein 2. Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance5 genes
ActA, ActA Protein. The ActA family is found in Listeria and is associated with motility. ActA protein acts as a scaffold to assemble and activate host cell actin cytoskeletal factors at the bacterial surface, resulting in directional actin po5 genes
ADK_lid, Adenylate kinase, active site lid. Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated5 genes
APC_basic, APC basic domain. This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules5 genes
ATP-dependent DNA helicase activity, IEA5 genes
arylsulfatase activity, TAS5 genes
actin filament, TAS5 genes
alcohol metabolism, TAS5 genes
ATP-dependent proteolysis, IEA5 genes
amino acid metabolism, NR5 genes
arginine biosynthesis, IEA5 genes
anion transport, TAS5 genes
anti-apoptosis, ISS5 genes
acute-phase response, TAS5 genes
axonogenesis, ISS5 genes
astacin activity, IEA5 genes
amiloride-sensitive sodium channel activity, TAS5 genes
amino acid permease activity, IEA5 genes
amino acid binding, IEA5 genes
ATPase activity, coupled, NAS5 genes
ATP-gua_Ptrans, ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain4 genes
Alk_phosphatase, Alkaline phosphatase4 genes
AIRS, AIR synthase related protein, N-terminal domain. This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The N-terminal domain of AIR sy4 genes
Aldolase_II, Class II Aldolase and Adducin N-terminal domain. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function4 genes
ACR_tran, AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the Acr4 genes
ART, NAD:arginine ADP-ribosyltransferase4 genes
Amidase_2, N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacter4 genes
ANATO, Anaphylotoxin-like domain. C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homol4 genes
ATP-gua_PtransN, ATP:guanido phosphotransferase, N-terminal domain. The N-terminal domain has an all-alpha fold4 genes
ATP_bind_1, Conserved hypothetical ATP binding protein. Members of this family are found in a range of archaea and eukaryotes and have hypothesised ATP binding activity4 genes
ArgK, ArgK protein. The ArgK protein acts as an ATPase enzyme and as a kinase, and phosphorylates periplasmic binding proteins involved in the LAO (lysine, arginine, ornithine)/AO transport systems4 genes
AMOP, AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disul4 genes
AAA_div, Divergent AAA domain. This family is related to the pfam00004 family, and presumably has the same function (ATP-binding)4 genes
AKAP_110, A-kinase anchor protein 110 kDa (AKAP 110). This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are p4 genes
Ald_N, ABC transporter N-terminus. This region covers the N-terminus and first two membrane regions of a small family of ABC transporters. Mutations in this domain in PMP70 are believed responsible for Zellweger Syndrome-2; mutations in ALDP a4 genes
actin binding, IDA4 genes
adenylate cyclase activity, IEA4 genes
aldehyde dehydrogenase (NAD) activity, IEA4 genes
aldehyde dehydrogenase [NAD(P)+] activity, IEA4 genes
aminomethyltransferase activity, IEA4 genes
aminopeptidase activity, TAS4 genes
aspartate-tRNA ligase activity, IEA4 genes
ATP-gated cation channel activity, TAS4 genes
ARF guanyl-nucleotide exchange factor activity, TAS4 genes
axonemal dynein complex, NAS4 genes
Arp2/3 protein complex, TAS4 genes
aspartyl-tRNA aminoacylation, IEA4 genes
amino acid metabolism, NAS4 genes
arginine catabolism, TAS4 genes
aspartate catabolism, TAS4 genes
autophagy, IEA4 genes
anti-apoptosis, NR4 genes
acetylcholine receptor signaling, muscarinic pathway, TAS4 genes
activation of NF-kappaB-inducing kinase, NAS4 genes
axonogenesis, NAS4 genes
aging, TAS4 genes
apoptotic mitochondrial changes, TAS4 genes
amino acid biosynthesis, IEA4 genes
actin cytoskeleton, NAS4 genes
ATPase activity, NAS4 genes
autophosphorylation, ISS4 genes
actin filament binding, TAS4 genes
ANP, Atrial natriuretic peptide3 genes
Aconitase, Aconitase family (aconitate hydratase)3 genes
Arginase, Arginase family3 genes
AdoHcyase_NAD, S-adenosyl-L-homocysteine hydrolase, NAD binding domain3 genes
Aconitase_C, Aconitase C-terminal domain. Members of this family usually also match to pfam00330. This domain undergoes conformational change in the enzyme mechanism3 genes
Acylphosphatase, Acylphosphatase3 genes
Asn_synthase, Asparagine synthase. This family is always found associated with pfam00310. Members of this family catalyse the conversion of aspartate to asparagine3 genes
Arginosuc_synth, Arginosuccinate synthase. This family contains a PP-loop motif3 genes
Asparaginase_2, Asparaginase3 genes
Alpha_L_fucos, Alpha-L-fucosidase3 genes
Amidase, Amidase3 genes
Arch_ATPase, Archaeal ATPase. This family contain a conserved P-loop motif that is involved in binding ATP. This family is almost exclusively found in archaebacteria and particularly in Methanococcus jannaschii that encodes sixteen members of 3 genes
Arylesterase, Arylesterase. This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyses organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to o3 genes
ACOX, Acyl-CoA oxidase. This is a family of Acyl-CoA oxidases EC:1.3.3.6. Acyl-coA oxidase converts acyl-CoA into trans-2- enoyl-CoA3 genes
ACT, ACT domain. This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino 3 genes
A4_EXTRA, Amyloid A4 extracellular domain3 genes
ATP-grasp, ATP-grasp domain. This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity3 genes
Amidinotransf, Amidinotransferase. This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively. This family also includes arginine deiminases3 genes
ArsA_ATPase, Anion-transporting ATPase. This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell3 genes
Alpha-amylase_C, Alpha amylase, C-terminal all-beta domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-bin3 genes
ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating gl3 genes
AIP3, Actin interacting protein 33 genes
ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that t3 genes
APG17, Autophagy protein Apg17. Apg17 is required for activating Apg1 protein kinases3 genes
APG12, Autophagy protein Apg12. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg12 is covalently bound to Apg53 genes
Asp_Arg_Hydrox, Aspartyl/Asparaginyl beta-hydroxylase. Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes. Proline 3-hydroxylase hydroxylates proline at position 3, the first of 3 genes
AdoHcyase, S-adenosyl-L-homocysteine hydrolase3 genes
Anth_Ig, Anthrax receptor extracellular domain. This region is found in the putatively extracellular N-terminal half of the anthrax receptor. It is probably part of the Ig superfamily and most closely related to pfam01833 (personal obs: C Yeat3 genes
Agenet, Agenet domain. This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family currently only matches one of the two Agenet domains in the FMR proteins3 genes
ATP-synt_S1, Vacuolar ATP synthase subunit S1 (ATP6S1). This family consists of eukaryotic vacuolar ATP synthase subunit S1 proteins3 genes
aPHC, Alkaline phytoceramidase (aPHC). This family consists of several eukaryotic Alkaline phytoceramidase (aPHC) sequences. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates. Al3 genes
activation of MAPKKK, TAS3 genes
angiogenesis, NAS3 genes
acid phosphatase activity, TAS3 genes
acylphosphatase activity, IEA3 genes
adenosine deaminase activity, TAS3 genes
ATP-dependent RNA helicase activity, NAS3 genes
adenylate cyclase activity, TAS3 genes
adenylate kinase activity, IEA3 genes
adenylate kinase activity, TAS3 genes
aldehyde dehydrogenase (NAD) activity, TAS3 genes
aldehyde reductase activity, TAS3 genes
amidase activity, IEA3 genes
aminoacylase activity, TAS3 genes
aryldialkylphosphatase activity, IEA3 genes
alpha-amylase activity, IEA3 genes
alpha-amylase activity, TAS3 genes
alpha-mannosidase activity, IEA3 genes
alanine-tRNA ligase activity, IEA3 genes
arginine-tRNA ligase activity, IEA3 genes
asialoglycoprotein receptor activity, TAS3 genes
alpha1-adrenergic receptor activity, TAS3 genes
alpha2-adrenergic receptor activity, TAS3 genes
angiotensin type II receptor activity, IEA3 genes
angiotensin type II receptor activity, TAS3 genes
ATP binding, NR3 genes
anaphase-promoting complex, TAS3 genes
alpha-ketoglutarate dehydrogenase complex (sensu Eukarya), TAS3 genes
ATP biosynthesis, IEA3 genes
apoptosis, IDA3 genes
apoptosis, ISS3 genes
acute-phase response, NAS3 genes
actin filament organization, TAS3 genes
activation of NF-kappaB-inducing kinase, ISS3 genes
anterograde axon cargo transport, TAS3 genes
actin polymerization and/or depolymerization, TAS3 genes
anion transporter activity, TAS3 genes
ammonium transporter activity, NAS3 genes
amine metabolism, TAS3 genes
amino acid transporter activity, IEA3 genes
ATP hydrolysis coupled proton transport, ISS3 genes
antioxidant activity, IEA3 genes
antioxidant activity, NAS3 genes
apical plasma membrane, NAS3 genes
antigen presentation, NAS3 genes
actin cytoskeleton organization and biogenesis, ISS3 genes
actin filament polymerization, TAS3 genes
actin filament-based movement, ISS3 genes
androgen receptor signaling pathway, NAS3 genes
autophosphorylation, IDA3 genes
actin filament bundle formation, TAS3 genes
AA_kinase, Amino acid kinase family. This family includes kinases that phosphorylate a variety of amino acid substrates, as well as uridylate kinase and carbamate kinase. This family includes: Aspartokinase EC:2.7.2.4. Acetylglutamate kinase E2 genes
Acyl_transf_1, Acyl transferase domain2 genes
Adenylsucc_synt, Adenylosuccinate synthetase2 genes
Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines a2 genes
Aminotran_4, Aminotransferase class IV. The D-amino acid transferases (D-AAT) are required by bacteria to catalyse the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building blo2 genes
ATP_bind_3, PP-loop family. This family of proteins belongs to the PP-loop superfamily2 genes
Ald_Xan_dh_C, Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain2 genes
APS_kinase, Adenylylsulphate kinase. Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif2 genes
ATP-sulfurylase, ATP-sulfurylase. This family consists of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase pfam01583. Bot2 genes
AMMECR1, AMMECR1. This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis an2 genes
Alpha_adaptin_C, Alpha adaptin AP2, C-terminal domain. Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to t2 genes
Adeno_terminal, Adenoviral DNA terminal protein. This protein is covalently attached to the terminii of replicating DNA in vivo2 genes
ALA_synthase, Aminolevulinic acid synthase domain. This Pfam domain is specific to 5-aminolevulinic acid (ALA) synthase which is involved in heme biosynthesis. The Aminotransferases class-II domain (pfam00222) is found to the C-terminus of thi2 genes
Ald_Xan_dh_C2, Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain2 genes
Alg6_Alg8, ALG6, ALG8 glycosyltransferase family. N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the 2 genes
Avirulence, Xanthomonas avirulence protein, Avr/PthA2 genes
Auxin_eff, Auxin Efflux Carrier. This family of transporters are found in all domains of life2 genes
ARPF, Aromatic-Rich Protein Family. This family may be related to polyketide synthases (pfam03364)2 genes
Autophagy_C, Autophagocytosis associated protein, C-terminal domain. Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole2 genes
ATP-synt_G, Mitochondrial ATP synthase g subunit. The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport. It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L). The function 2 genes
Anti-silence, Anti-silencing protein, ASF1-like. This family includes the yeast ASF1 protein, which derepresses transcriptionally silenced genes. The human ASF1 homologue has been found to possess histone chaperone activity, which may explain 2 genes
AMPKBI, 5'-AMP-activated protein kinase, beta subunit, complex-interacting region. This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the S2 genes
Agouti, Agouti protein. The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at 2 genes
Amelin, Ameloblastin precursor (Amelin). This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although thei2 genes
AMP_N, Aminopeptidase P, N-terminal domain. This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families2 genes
AlaDh_PNT_N, Alanine dehydrogenase/PNT, N-terminal domain. This family now also contains the lysine 2-oxoglutarate reductases2 genes
AXE1, Acetyl xylan esterase (AXE1). This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieti2 genes
ATP_synt_H, ATP synthase subunit H. ATP synthase subunit H is an extremely hydrophobic of approximately 9 kDa. This subunit may be required for assembly of vacuolar ATPase2 genes
Ant_C, Anthrax receptor C-terminus region. This region is found in the putatively cytoplasmic C-terminus of the anthrax receptor2 genes
Aph-1, Aph-1 protein. This family consists of several eukaryotic Aph-1 proteins.Gamma-secretase catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a2 genes
Ad_Cycl_assoc, Adenylate cyclase associated. This region is found in several bacterial transcriptional regulators and putative adenylate cyclases. It appears to contain sequences that share some sequence similarity with pfam005152 genes
Ataxin-2_N, Ataxin-2 N-terminal region. This family represents a conserved region approximately 250 residues long located towards the C-terminus of eukaryotic ataxin-2. Ataxin-2 is a protein of unknown function, within which expansion of a pol2 genes
Ataxin-2_C, Ataxin-2 C-terminal region. This family represents a conserved region approximately 250 residues long located towards the C-terminus of eukaryotic ataxin-2. Ataxin-2 is a protein of unknown function, within which expansion of a pol2 genes
acyl-CoA binding, TAS2 genes
activation of MAPKK, TAS2 genes
activation of MAPK, IDA2 genes
angiogenesis, IDA2 genes
AT DNA binding, TAS2 genes
antigen binding, NAS2 genes
antigen binding, NR2 genes
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, IEA2 genes
AMP deaminase activity, TAS2 genes
acetyl-CoA C-acetyltransferase activity, TAS2 genes
acetyl-CoA C-acyltransferase activity, IEA2 genes
acyl-CoA dehydrogenase activity, IEA2 genes
acyl-CoA dehydrogenase activity, TAS2 genes
acyl-CoA oxidase activity, TAS2 genes
acylphosphatase activity, TAS2 genes
ATP-dependent RNA helicase activity, ISS2 genes
ATP-binding cassette (ABC) transporter activity, NR2 genes
adenylate cyclase activity, NAS2 genes
adenylyl-sulfate kinase activity, IEA2 genes
alcohol dehydrogenase activity, zinc-dependent, NAS2 genes
alcohol dehydrogenase activity, zinc-dependent, TAS2 genes
alkaline phosphatase activity, IEA2 genes
alkaline phosphatase activity, NAS2 genes
anthranilate synthase activity, IEA2 genes
apyrase activity, IEA2 genes
arachidonate 12-lipoxygenase activity, TAS2 genes
arginase activity, TAS2 genes
aryl sulfotransferase activity, IEA2 genes
arylesterase activity, NAS2 genes
arylsulfatase activity, IDA2 genes
asparaginase activity, IEA2 genes
aspartate transaminase activity, IEA2 genes
alpha-glucosidase activity, IEA2 genes
atypical protein kinase C activity, TAS2 genes
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, NR2 genes
androgen binding, NAS2 genes
androgen binding, TAS2 genes
ATP binding, IC2 genes
alpha DNA polymerase:primase complex, NR2 genes
anaphase-promoting complex, NR2 genes
adherens junction, NAS2 genes
amino sugar metabolism, TAS2 genes
alcohol metabolism, NAS2 genes
acetyl-CoA metabolism, IEA2 genes
acetyl-CoA biosynthesis, NAS2 genes
alanyl-tRNA aminoacylation, IEA2 genes
arginyl-tRNA aminoacylation, IEA2 genes
asparaginyl-tRNA aminoacylation, IEA2 genes
anti-apoptosis, IEA2 genes
actin filament organization, IDA2 genes
actin filament organization, ISS2 genes
activation of NF-kappaB-inducing kinase, IDA2 genes
acrosome reaction, NAS2 genes
acrosome reaction, TAS2 genes
axon guidance, NAS2 genes
axon guidance, NR2 genes
androgen metabolism, TAS2 genes
acetylglucosaminyltransferase activity, IEA2 genes
acetylglucosaminyltransferase activity, TAS2 genes
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, TAS2 genes
aspartic-type signal peptidase activity, IEA2 genes
amino acid transporter activity, TAS2 genes
ATP-activated inward rectifier potassium channel activity, IEA2 genes
amiloride-sensitive sodium channel activity, IEA2 genes
ammonium transport, NAS2 genes
aminophospholipid transport, NAS2 genes
aldolase activity, IEA2 genes
apical plasma membrane, IDA2 genes
ATPase activity, ISS2 genes
activin inhibitor activity, TAS2 genes
antibacterial humoral response (sensu Vertebrata), TAS2 genes
aspartoacylase activity, IEA2 genes
antigen processing, endogenous antigen via MHC class I, NAS2 genes
actin cytoskeleton organization and biogenesis, IDA2 genes
actin filament-based movement, TAS2 genes
AP-1 adaptor complex, ISS2 genes
AP-2 adaptor complex, NAS2 genes
anti-inflammatory response, NAS2 genes
anti-inflammatory response, TAS2 genes
apoptotic nuclear changes, IDA2 genes
ADP-ribosylation factor binding, IDA2 genes
antigen processing, NAS2 genes
axon, NAS2 genes
ankyrin binding, IDA2 genes
ankyrin binding, IPI2 genes
ATPase activity, uncoupled, IEA2 genes
adipocyte differentiation, NAS2 genes
ATP metabolism, IEA2 genes
antigen presentation, endogenous peptide antigen, NAS2 genes
arachidonate 15-lipoxygenase activity, IEA2 genes
AF-2 domain binding, IPI2 genes
actin filament binding, NR2 genes
actin filament bundle formation, NR2 genes
ATP-synt, ATP synthase1 genes
ALAD, Delta-aminolevulinic acid dehydratase1 genes
Asparaginase, Asparaginase1 genes
AIRC, AIR carboxylase. Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain t1 genes
ACTH_domain, Corticotropin ACTH domain1 genes
Ala_racemase_N, Alanine racemase, N-terminal domain1 genes
AP_endonuc_2, AP endonuclease family 21 genes
Aldose_epim, Aldose 1-epimerase1 genes
Antifreeze, Antifreeze-like domain. This family contains type III antifreeze proteins as well as a variety of enzymes. This domain is presumed to be involved in sugar binding in the enzyme proteins1 genes
ACPS, 4'-phosphopantetheinyl transferase superfamily. Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pfam00550. This post-translational modification renders holo-ACP c1 genes
AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme. This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is cat1 genes
ATP-synt_D, ATP synthase subunit D. This is a family of subunit D form various ATP synthases including V-type H+ transporting and Na+ dependent. Subunit D is suggested to be an integral part of the catalytic sector of the V-ATPase1 genes
ATP_bind_4, ATP-binding region. This family of proteins probably binds ATP. This domain is about 200 amino acids long with a strongly conserved motif SGGKD at the N terminus. In some members of this family, this domain is associated with pfam01 genes
ATP-synt_F, ATP synthase (F/14-kDa) subunit. This family includes 14-kDa subunit from vATPases, which is in the peripheral catalytic part of the complex. The family also includes archaebacterial ATP synthase subunit F1 genes
Adrenomedullin, Adrenomedullin1 genes
ArsB, Arsenical pump membrane protein1 genes
Abi, CAAX amino terminal protease family. Members of this family are probably proteases; the family contains CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also cont1 genes
Acyl_CoA_thio, Acyl-CoA thioesterase. This family represents the thioesterase II domain. Two copies of this domain are found in a number of acyl-CoA thioesterases1 genes
Adeno_E1A, Early E1A protein. This is a family of adenovirus early E1A proteins. The E1A protein is 32 kDa it can however be cleaved to yield the 28 kDa protein. The E1A protein is responsible for the transcriptional activation of the early ge1 genes
ATP-synt_DE_N, ATP synthase, Delta/Epsilon chain, beta-sandwich domain. Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria. In bacte1 genes
ARD, ARD/ARD' family. The two acireductone dioxygenase enzymes (ARD and ARD', previously known as E-2 and E-2') from Klebsiella pneumoniae share the same amino acid sequence, but bind different metal ions: ARD binds Ni2+, ARD' binds Fe2+. ARD 1 genes
ATP-cone, ATP cone domain1 genes
Arg_tRNA_synt_N, Arginyl tRNA synthetase N terminal domain. This domain is found at the amino terminus of Arginyl tRNA synthetase, also called additional domain 1 (Add-1). It is about 140 residues long and it has been suggested that this domai1 genes
Allantoicase, Allantoicase repeat. This family is found in pairs in Allantoicases, forming the majority of the protein. These proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction:1 genes
AFG1_ATPase, AFG1-like ATPase. This family of proteins contains a P-loop motif and are predicted to be ATPases1 genes
Autophagy_N, Autophagocytosis associated protein, N-terminal domain. Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole1 genes
APC8, Anaphase promoting complex subunit 8 / Cdc23. The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8)1 genes
APG5, Autophagy protein Apg5. Apg5 is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway1 genes
APG9, Autophagy protein Apg9. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm t1 genes
Arv1, Arv1-like family. Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis1 genes
ATE_N, Arginine-tRNA-protein transferase, N terminus. This family represents the N terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus o1 genes
ATE_C, Arginine-tRNA-protein transferase, C terminus. This family represents the C terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus o1 genes
ADP_PFK_GK, ADP-specific Phosphofructokinase/Glucokinase conserved region. In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilises two novel proteins: an ADP-depend1 genes
ATP-synt_Eps, Mitochondrial ATP synthase epsilon chain. This family constitutes the mitochondrial ATP synthase epsilon subunit. This is not to be confused with the bacterial epsilon subunit, which is homologous to the mitochondrial delta subun1 genes
ARM_1, Adhesion regulating molecule conserved region. Family of eukaryotic proteins involved in cell adhesion. Members are involved in gastrulation and metastatic cancer formation. Experimental evidence suggests that members are transmembrane 1 genes
ApoC-I, Apolipoprotein C-I (ApoC-1). Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solublises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very1 genes
AMH_N, Anti-Mullerian hormone, N terminal region. Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a1 genes
ApoA-II, Apolipoprotein A-II (ApoA-II). Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridg1 genes
Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam019791 genes
ALG3, ALG3 protein. The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur o1 genes
Asp-B-Hydro_N, Aspartyl beta-hydroxylase N-terminal region. This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which come1 genes
AAR2, AAR2 protein. This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth1 genes
Apo-CII, Apolipoprotein C-II. Apolipoprotein C-II (ApoC-II) is the major activator of lipoprotein lipase, a key enzyme in the regulation of triglyceride levels in human serum1 genes
ATP-synt_F6, Mitochondrial ATP synthase coupling factor 6. Coupling factor 6 (F6) is a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments1 genes
ATP-synt_E, ATP synthase E chain. This family consists of several ATP synthase E chain sequences which are components of the CF(0) subunit1 genes
Apo-CIII, Apolipoprotein CIII (Apo-CIII). This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesised in the intestine and liver as part of the very l1 genes
ARPC4, ARP2/3 complex 20 kDa subunit (ARPC4). This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The huma1 genes
ACN9, ACN9 family. Mutants of the yeast ACN9 gene have two- to fourfold elevated levels of enzymes of the glyoxylate cycle, gluconeogenesis, and acetyl-CoA metabolism. The ACN9 protein was localised to the mitochondrial intermembrane space1 genes
APC_crr, APC cysteine-rich region. This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These 1 genes
Apyrase, Apyrase. This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through 1 genes
AGTRAP, Angiotensin II, type I receptor-associated protein (AGTRAP). This family consists of several angiotensin II, type I receptor-associated protein (AGTRAP) sequences. AGTRAP is known to interact specifically with the carboxyl-terminal cyt1 genes
Alpha-2-MRAP_N, Alpha-2-macroglobulin RAP, N-terminal domain. The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprote1 genes
Alpha-2-MRAP_C, Alpha-2-macroglobulin RAP, C-terminal domain. The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprote1 genes
ATP11, ATP11 protein. This family consists of several eukaryotic ATP11 proteins. In Saccharomyces cerevisiae, expression of functional F1-ATPase requires two proteins encoded by the ATP11 and ATP12 genes1 genes
Auto_anti-p27, Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27). This family consists of several Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) sequences. It is thought that the potential association of anti-p27 w1 genes
ANKH, Progressive ankylosis protein (ANKH). This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of p1 genes
acyl carrier activity, IEA1 genes
autophagic vacuole formation, IEA1 genes
activation of MAPKK, IDA1 genes
activation of MAPK, ISS1 genes
activation of MAPK, NAS1 genes
assembly of spliceosomal tri-snRNP, NAS1 genes
assembly of spliceosomal tri-snRNP, NR1 genes
assembly of spliceosomal tri-snRNP, TAS1 genes
age-dependent response to reactive oxygen species, IMP1 genes
age-dependent response to reactive oxygen species, ISS1 genes
acetylcholine breakdown in synaptic cleft, NAS1 genes
acetylcholine breakdown in synaptic cleft, TAS1 genes
angiogenesis, TAS1 genes
A1 adenosine receptor activity, G-protein coupled, IEA1 genes
A2A adenosine receptor activity, G-protein coupled, IEA1 genes
A2B adenosine receptor activity, G-protein coupled, IEA1 genes
A3 adenosine receptor activity, G-protein coupled, IEA1 genes
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity, IEA1 genes
ATPase stimulator activity, TAS1 genes
aminocarboxymuconate-semialdehyde decarboxylase activity, IDA1 genes
actin monomer binding, IDA1 genes
actin monomer binding, NR1 genes
alternative-complement-pathway C3/C5 convertase activity, IEA1 genes
antigen binding, IPI1 genes
antigen binding, ISS1 genes
alpha-ketoacid dehydrogenase activity, TAS1 genes
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, IEA1 genes
ADP-ribosylarginine hydrolase activity, TAS1 genes
AMP deaminase activity, NAS1 genes
ATP citrate synthase activity, TAS1 genes
alpha DNA polymerase activity, NAS1 genes
alkylbase DNA N-glycosylase activity, IEA1 genes
acetyl-CoA hydrolase activity, IEA1 genes
acetate-CoA ligase activity, IDA1 genes
acetate-CoA ligase activity, IEA1 genes
acetyl-CoA C-acyltransferase activity, TAS1 genes
acetyl-CoA carboxylase activity, NR1 genes
acetyl-CoA carboxylase activity, TAS1 genes
acetylcholinesterase activity, IEA1 genes
acetylcholinesterase activity, IMP1 genes
acetylglutamate kinase activity, IEA1 genes
aconitate hydratase activity, IDA1 genes
aconitate hydratase activity, IEA1 genes
aconitate hydratase activity, NR1 genes
acyl-CoA dehydrogenase activity, IMP1 genes
acyl-CoA ligase activity, IDA1 genes
acyl-CoA oxidase activity, NAS1 genes
adenine phosphoribosyltransferase activity, TAS1 genes
adenosine deaminase activity, IEA1 genes
adenosine kinase activity, TAS1 genes
ATP-dependent RNA helicase activity, NR1 genes
adenosylhomocysteinase activity, IEA1 genes
adenosylhomocysteinase activity, TAS1 genes
adenylate kinase activity, NR1 genes
adenylosuccinate lyase activity, TAS1 genes
adenylosuccinate synthase activity, IEA1 genes
adenylosuccinate synthase activity, TAS1 genes
alanine transaminase activity, NAS1 genes
alcohol dehydrogenase activity, IDA1 genes
alcohol dehydrogenase activity, ISS1 genes
alcohol dehydrogenase activity, TAS1 genes
alcohol sulfotransferase activity, IEA1 genes
aldehyde dehydrogenase (NAD) activity, ISS1 genes
aldehyde dehydrogenase [NAD(P)+] activity, TAS1 genes
aldehyde oxidase activity, TAS1 genes
aldo-keto reductase activity, ISS1 genes
aldose 1-epimerase activity, IEA1 genes
amidase activity, TAS1 genes
amino-acid N-acetyltransferase activity, IEA1 genes
amidophosphoribosyltransferase activity, TAS1 genes
aminoacyl-tRNA hydrolase activity, IEA1 genes
aminomethyltransferase activity, TAS1 genes
arachidonate 5-lipoxygenase activity, TAS1 genes
arginase activity, IEA1 genes
argininosuccinate synthase activity, IEA1 genes
argininosuccinate lyase activity, TAS1 genes
arginyltransferase activity, TAS1 genes
aromatic-L-amino-acid decarboxylase activity, TAS1 genes
aralkylamine N-acetyltransferase activity, TAS1 genes
arylamine N-acetyltransferase activity, TAS1 genes
aryl sulfotransferase activity, TAS1 genes
arylesterase activity, IEA1 genes
arylesterase activity, TAS1 genes
asparagine synthase (glutamine-hydrolyzing) activity, IDA1 genes
aspartate carbamoyltransferase activity, IEA1 genes
amylo-alpha-1,6-glucosidase activity, IEA1 genes
ATP-dependent peptidase activity, TAS1 genes
aspartic-type endopeptidase activity, IEA1 genes
aminopeptidase I activity, IEA1 genes
acylaminoacyl-peptidase activity, TAS1 genes
acrosin activity, TAS1 genes
alpha,alpha-trehalase activity, IDA1 genes
alpha-galactosidase activity, IEA1 genes
alpha-glucosidase activity, TAS1 genes
alpha-mannosidase activity, TAS1 genes
alpha-L-fucosidase activity, IEA1 genes
alpha-L-fucosidase activity, TAS1 genes
alpha-N-acetylglucosaminidase activity, TAS1 genes
AMP-activated protein kinase activity, TAS1 genes
atypical protein kinase C activity, ISS1 genes
aspartate-tRNA ligase activity, TAS1 genes
asparagine-tRNA ligase activity, IEA1 genes
asparagine-tRNA ligase activity, TAS1 genes
androgen receptor activity, IEA1 genes
androgen receptor activity, NAS1 genes
androgen receptor activity, TAS1 genes
alpha1-adrenergic receptor activity, IEA1 genes
alpha1-adrenergic receptor activity, NAS1 genes
angiotensin type II receptor activity, NAS1 genes
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, TAS1 genes
adrenocorticotropin receptor activity, TAS1 genes
aryl hydrocarbon receptor nuclear translocator activity, NAS1 genes
aryl hydrocarbon receptor nuclear translocator activity, TAS1 genes
ARF guanyl-nucleotide exchange factor activity, ISS1 genes
ARF guanyl-nucleotide exchange factor activity, NAS1 genes
ATP-binding and phosphorylation-dependent chloride channel activity, TAS1 genes
A-type (transient outward) potassium channel activity, TAS1 genes
acetylcholine transporter activity, TAS1 genes
ATP:ADP antiporter activity, NAS1 genes
alpha DNA polymerase:primase complex, TAS1 genes
anaphase-promoting complex, IDA1 genes
anaphase-promoting complex, NAS1 genes
axonemal dynein complex, TAS1 genes
actin filament, NAS1 genes
adherens junction, IDA1 genes
axoneme, TAS1 genes
alpha-ketoglutarate dehydrogenase complex (sensu Eukarya), NAS1 genes
alpha-ketoglutarate dehydrogenase complex (sensu Eukarya), NR1 genes
aminoglycan biosynthesis, NR1 genes
alcohol metabolism, NR1 genes
aldehyde metabolism, ISS1 genes
acetyl-CoA metabolism, NR1 genes
acetyl-CoA metabolism, TAS1 genes
AMP biosynthesis, TAS1 genes
adenine salvage, IEA1 genes
ADP biosynthesis, TAS1 genes
AMP catabolism, TAS1 genes
ATP catabolism, TAS1 genes
alanyl-tRNA aminoacylation, TAS1 genes
arginyl-tRNA aminoacylation, TAS1 genes
aspartyl-tRNA aminoacylation, TAS1 genes
ATP-dependent proteolysis, NAS1 genes
amino acid and derivative metabolism, IEA1 genes
arginine metabolism, NAS1 genes
arginine biosynthesis, NAS1 genes
arginine catabolism, IEA1 genes
arginine catabolism, NR1 genes
asparagine biosynthesis, NAS1 genes
amino acid derivative metabolism, TAS1 genes
acyl-CoA metabolism, IEA1 genes
acyl-CoA metabolism, NAS1 genes
acyl-CoA metabolism, NR1 genes
acyl-CoA metabolism, TAS1 genes
androgen biosynthesis, NAS1 genes
androgen biosynthesis, TAS1 genes
androgen catabolism, NR1 genes
ATP biosynthesis, ISS1 genes
amino acid transport, TAS1 genes
autophagy, TAS1 genes
apoptosis, IEP1 genes
apoptosis, IMP1 genes
acute-phase response, IDA1 genes
acute-phase response, NR1 genes
anti-Gram-positive bacterial polypeptide induction, TAS1 genes
actin filament organization, IMP1 genes
actin filament organization, NAS1 genes
adenylate cyclase activation, NR1 genes
activation of JUNK, IDA1 genes
activation of JUNK, ISS1 genes
activation of JUNK, NAS1 genes
anterior compartment specification, NR1 genes
anterior compartment specification, TAS1 genes
axon guidance, ISS1 genes
adult heart development, NAS1 genes
ATP-dependent helicase activity, ISS1 genes
ATP-dependent helicase activity, NAS1 genes
axon guidance receptor activity, TAS1 genes
ARF GTPase activator activity, IDA1 genes
axon cargo transport, TAS1 genes
anterograde axon cargo transport, ISS1 genes
asymmetric protein localization, TAS1 genes
alcohol dehydrogenase (NADP+) activity, IEA1 genes
alpha-methylacyl-CoA racemase activity, IEA1 genes
amine oxidase activity, NR1 genes
amine oxidase activity, TAS1 genes
actin polymerization and/or depolymerization, ISS1 genes
androgen metabolism, IDA1 genes
androgen metabolism, ISS1 genes
acetylcholine biosynthesis, NAS1 genes
adult feeding behavior, TAS1 genes
acetylgalactosaminyltransferase activity, IDA1 genes
arachidonic acid epoxygenase activity, TAS1 genes
aromatase activity, TAS1 genes
alanine-glyoxylate transaminase activity, IEA1 genes
alanine-glyoxylate transaminase activity, NAS1 genes
alanine-glyoxylate transaminase activity, TAS1 genes
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, NR1 genes
alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, TAS1 genes
alpha-N-acetylgalactosaminidase activity, TAS1 genes
acetyl-CoA transporter activity, TAS1 genes
alkylglycerone-phosphate synthase activity, IEA1 genes
activation of pro-apoptotic gene products, NAS1 genes
apoptotic mitochondrial changes, NAS1 genes
amino acid biosynthesis, TAS1 genes
acyl-CoA thioesterase II activity, TAS1 genes
agmatinase activity, IEA1 genes
alanine racemase activity, IEA1 genes
alkyl hydroperoxide reductase activity, TAS1 genes
arsenate reductase (glutaredoxin) activity, TAS1 genes
amine biosynthesis, TAS1 genes
aspartate carbamoyltransferase complex, IEA1 genes
aminobutyrate metabolism, IEA1 genes
aminobutyrate catabolism, TAS1 genes
auditory hair cell fate commitment, ISS1 genes
arsenite transporter activity, IEA1 genes
arsenite transporter activity, TAS1 genes
acidic amino acid transporter activity, NAS1 genes
adenine transporter activity, TAS1 genes
ATP-activated inward rectifier potassium channel activity, TAS1 genes
amiloride-sensitive sodium channel activity, NAS1 genes
amiloride-sensitive sodium channel activity, NR1 genes
apoptogenic cytochrome c release channel activity, TAS1 genes
arsenite-transporting ATPase activity, IEA1 genes
auxiliary transport protein activity, NR1 genes
auxiliary transport protein activity, TAS1 genes
acetylcholine receptor activity, IDA1 genes
acetylcholine receptor activity, NR1 genes
actin cytoskeleton, IDA1 genes
actin cytoskeleton, IEP1 genes
actin cytoskeleton, ISS1 genes
alpha-ketoglutarate transport, TAS1 genes
acidic amino acid transport, NAS1 genes
adenine transport, TAS1 genes
acetylcholine transport, TAS1 genes
ATP synthesis coupled proton transport, TAS1 genes
ATP hydrolysis coupled proton transport, TAS1 genes
AMP binding, IC1 genes
ammonia ligase activity, IEA1 genes
acyl-CoA thioesterase activity, IEA1 genes
acyl-CoA thioesterase activity, NAS1 genes
acyl-CoA thioesterase activity, TAS1 genes
apical plasma membrane, ISS1 genes
acetyltransferase activity, IEA1 genes
apoptotic protease activator activity, NAS1 genes
ATPase activity, IDA1 genes
ATPase activity, TAS1 genes
acetylserotonin O-methyltransferase activity, IEA1 genes
acetylserotonin O-methyltransferase activity, NAS1 genes
activin inhibitor activity, NAS1 genes
aryl hydrocarbon receptor binding, ISS1 genes
alkane 1-monooxygenase activity, IEA1 genes
arsonoacetate metabolism, ISS1 genes
ADP-sugar diphosphatase activity, IDA1 genes
ADP-sugar diphosphatase activity, NAS1 genes
aminobutyraldehyde dehydrogenase activity, IEA1 genes
arachidonic acid metabolism, NAS1 genes
antibacterial humoral response (sensu Vertebrata), NAS1 genes
antifungal humoral response (sensu Vertebrata), NAS1 genes
antimicrobial humoral response (sensu Vertebrata), NAS1 genes
antigen processing, endogenous antigen via MHC class I, ISS1 genes
antigen processing, exogenous antigen via MHC class II, IDA1 genes
axon transport of mitochondrion, TAS1 genes
actin cytoskeleton organization and biogenesis, IGI1 genes
actin cytoskeleton organization and biogenesis, IMP1 genes
actin cytoskeleton organization and biogenesis, NR1 genes
actin filament polymerization, IDA1 genes
actin filament polymerization, NAS1 genes
actin filament polymerization, NR1 genes
actin modification, NAS1 genes
AP-1 adaptor complex, TAS1 genes
AP-2 adaptor complex, TAS1 genes
alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity, NAS1 genes
apolipoprotein E receptor activity, IDA1 genes
apoptotic chromosome condensation, IDA1 genes
ankyrin binding, ISS1 genes
ankyrin binding, NAS1 genes
androgen receptor signaling pathway, ISS1 genes
aminopeptidase B activity, NAS1 genes
amine N-methyltransferase activity, IEA1 genes
arsenite methyltransferase activity, ISS1 genes
apolipoprotein B mRNA editing enzyme complex, ISS1 genes
ATPase inhibitor activity, IEA1 genes
acetylcholine binding, NAS1 genes
azurophil granule, IDA1 genes
actomyosin, NAS1 genes
ATP synthesis coupled electron transport, IEA1 genes
amyloid precursor protein metabolism, NAS1 genes
amyloid precursor protein metabolism, TAS1 genes
ATP-dependent protein binding, IDA1 genes
actin nucleation, ISS1 genes
adipocyte differentiation, ISS1 genes
ATP metabolism, ISS1 genes
ATP metabolism, NAS1 genes
acid secretion, IDA1 genes
autophosphorylation, NAS1 genes
acylglycerol lipase activity, IEA1 genes
acyl-CoA dehydrogenase (NADP+) activity, IEA1 genes
ADP-ribose diphosphatase activity, IEA1 genes
antigen presentation, endogenous peptide antigen, ISS1 genes
antigen presentation, endogenous lipid antigen, IDA1 genes
astrocyte activation, ISS1 genes
alveolus development, IMP1 genes
arachidonic acid secretion, IDA1 genes
acyloxyacyl hydrolase activity, IEA1 genes
androgen receptor binding, IDA1 genes
AF-2 domain binding, ISS1 genes
apolipoprotein E receptor binding, NAS1 genes
antigen receptor-mediated signaling pathway, TAS1 genes
actin filament severing, IDA1 genes
actin filament severing, TAS1 genes
actin filament binding, ISS1 genes
actin filament binding, NAS1 genes
actin filament bundle formation, NAS1 genes
AS3D: Alternative Splicing Structural Genomics Projects
CARB/UMBI